A paradigm shift in oxygen sensing with a twist in the tale!

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dc.contributor.author O'Halloran, Ken D.
dc.date.accessioned 2017-03-21T09:33:32Z
dc.date.available 2017-03-21T09:33:32Z
dc.date.issued 2016-08-30
dc.identifier.citation O'Halloran, K. D. (2016) 'A paradigm shift in oxygen sensing with a twist in the tale!', Biochemical Journal, 473(17), pp.2687-2689; doi: 10.1042/BCJ20160500 en
dc.identifier.volume 473 en
dc.identifier.issued 17 en
dc.identifier.startpage 2687 en
dc.identifier.endpage 2689 en
dc.identifier.issn 0264-6021
dc.identifier.uri http://hdl.handle.net/10468/3791
dc.identifier.doi 10.1042/BCJ20160500
dc.description.abstract AMP-activated protein kinase (AMPK) is pivotal to metabolic homeostasis in eukaryotes, serving as a critical energy sensor. Increased AMPK activity during oxygen deprivation (hypoxia) protects against potentially catastrophic deficits in ATP supply. Whilst the nervous system circuitry for elaboration of the complex cardiorespiratory response to hypoxia has been understood in some detail for many decades, there is continued and considerable interest in the molecular machinery underpinning the mechanism(s) of oxygen sensing. In this issue of the Biochemical Journal, Evans et al. (2016) review their recent work, which points to a pivotal role for AMPK in the transduction of cellular hypoxic stress to integrated ventilatory behaviour, critical in the defence of whole-body oxygen homeostasis. Of great surprise, there is profound blunting of the hyperventilatory response to hypoxic stress in AMPK deficient mice, with resultant dysregulated breathing arising in spite of normal peripheral oxygen sensing and appropriate sensory input to the brain! Their pointedly provocative review challenges current dogma, and in doing so raises intriguing questions that probe fundamental aspects of our understanding of the mammalian ventilatory response to hypoxic stress. The engaging review by Evans et al. (2016) is an interesting read that is sure to encourage colourful debate. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Portland Press Ltd en
dc.rights © 2016, the Author. Published by Portland Press Limited on behalf of the Biochemical Society. en
dc.subject Activated protein kinase en
dc.subject Ventilatory response en
dc.subject Homeostasis en
dc.subject Metabolism en
dc.subject Hypoxia en
dc.subject Carotid body en
dc.title A paradigm shift in oxygen sensing with a twist in the tale! en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ken O'Halloran, Physiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: k.ohalloran@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this item is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2017-08-30
dc.date.updated 2017-03-18T12:59:39Z
dc.description.version Accepted Version en
dc.internal.rssid 387617924
dc.internal.wokid WOS:000393751200012
dc.description.status Peer reviewed en
dc.identifier.journaltitle Biochemical Journal en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.placepublication LONDON en
dc.internal.IRISemailaddress k.ohalloran@ucc.ie en

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