Microbiota regulates visceral pain in the mouse

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dc.contributor.author Luczynski, Pauline
dc.contributor.author Tramullas, Monica
dc.contributor.author Viola, Maria F.
dc.contributor.author Shanahan, Fergus
dc.contributor.author Clarke, Gerard
dc.contributor.author O'Mahony, Siobhain M.
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.date.accessioned 2017-09-26T11:39:19Z
dc.date.available 2017-09-26T11:39:19Z
dc.date.issued 2017
dc.identifier.citation Luczynski, P., Tramullas, M., Viola, M., Shanahan, F., Clarke, G., O'Mahony, S., Dinan, T. G. and Cryan, J. F. (2017) 'Microbiota regulates visceral pain in the mouse', eLife, 6, e25887. (21pp). doi: 10.7554/eLife.25887 en
dc.identifier.volume 6
dc.identifier.issn 2050-084X
dc.identifier.uri http://hdl.handle.net/10468/4786
dc.identifier.doi 10.7554/eLife.25887
dc.description.abstract The perception of visceral pain is a complex process involving the spinal cord and higher order brain structures. Increasing evidence implicates the gut microbiota as a key regulator of brain and behavior, yet it remains to be determined if gut bacteria play a role in visceral sensitivity. We used germ-free mice (GF) to assess visceral sensitivity, spinal cord gene expression and pain-related brain structures. GF mice displayed visceral hypersensitivity accompanied by increases in Toll-like receptor and cytokine gene expression in the spinal cord, which were normalized by postnatal colonization with microbiota from conventionally colonized (CC). In GF mice, the volumes of the anterior cingulate cortex (ACC) and periaqueductal grey, areas involved in pain processing, were decreased and enlarged, respectively, and dendritic changes in the ACC were evident. These findings indicate that the gut microbiota is required for the normal visceral pain sensation. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher eLife Sciences Publications Ltd en
dc.relation.uri https://elifesciences.org/articles/25887#
dc.rights © 2017, Luczynski et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Irritable bowel syndrome en
dc.subject Medial prefrontal cortex en
dc.subject Gut brain axis en
dc.subject Colorectal distension en
dc.subject Rectal distension en
dc.subject Pathological pain en
dc.subject Opioid analgesia en
dc.subject Neuropathic pain en
dc.subject Host microbiota en
dc.subject Stress response en
dc.title Microbiota regulates visceral pain in the mouse en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John F Cryan, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. +353-21-490-3000 E-mail: j.cryan@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.wokid WOS:000403660800001
dc.contributor.funder European Commission
dc.contributor.funder Science Foundation Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle eLife en
dc.internal.IRISemailaddress j.cryan@ ucc.ie en
dc.identifier.articleid e25887
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUT


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© 2017, Luczynski et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. Except where otherwise noted, this item's license is described as © 2017, Luczynski et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
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