Finding the needle in the haystack: systematic identification of psychobiotics

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Date
2017-12-15
Authors
Bambury, Aisling
Sandhu, Kiran V.
Cryan, John F.
Dinan, Timothy G.
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Wiley
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Abstract
The brain-gut-microbiota axis is increasingly viewed as a novel paradigm in neuroscience with the capacity to generate innovative therapies for patients with psychiatric illnesses. Psychobiotics, defined as live bacteria which when ingested in adequate amounts confer mental health benefits, are increasingly of interest, as pre-clinical trials continue to show promising results. Particularly in stress related, anxiety and depressive disorders, there is potential for psychobiotics to deliver new therapies. The question of which microbes may prove to be the most promising psychobiotic in delivering such therapies at clinical level is of great importance. Here we look at the characteristics of psychobiotics, in an attempt to present an outline, from which the identification of potential new psychobiotics may be possible.
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Keywords
Brain-gut-microbiota axis , Psychobiotics , Psychiatric illness , Neuroscience , Stress , Depressive disorders
Citation
Bambury, A., Sandhu, K., Cryan, J. F. and Dinan, T. G. 'Finding the needle in the haystack: systematic identification of psychobiotics', British Journal of Pharmacology, In Press, doi: 10.1111/bph.14127
Copyright
© 2017 The British Pharmacological Society. Published by Wiley. This is the peer reviewed version of the following article: Bambury, A., Sandhu, K., Cryan, J. F., and Dinan, T. G. (2017) Finding the needle in the haystack: systematic identification of psychobiotics. British Journal of Pharmacology, which has been published in final form at http://dx.doi.org/10.1111/bph.14127. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.