Is there a link between aging and microbiome diversity in exceptional mammalian longevity?

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dc.contributor.author Hughes, Graham M.
dc.contributor.author Leech, John
dc.contributor.author Puechmaille, Sebastien J.
dc.contributor.author Lopez, Jose V.
dc.contributor.author Teeling, Emma C.
dc.date.accessioned 2018-02-20T13:24:11Z
dc.date.available 2018-02-20T13:24:11Z
dc.date.issued 2018
dc.identifier.citation Hughes, G. M., Leech, J., Puechmaille, S. J., Lopez, J. V. and Teeling, E. C. (2018) 'Is there a link between aging and microbiome diversity in exceptional mammalian longevity?', PeerJ, 6, e4174 (21pp). doi: 10.7717/peerj.4174 en
dc.identifier.volume 6
dc.identifier.startpage 1
dc.identifier.endpage 21
dc.identifier.issn 2167-8359
dc.identifier.uri http://hdl.handle.net/10468/5492
dc.identifier.doi 10.7717/peerj.4174
dc.description.abstract A changing microbiome has been linked to biological aging in mice and humans, suggesting a possible role of gut flora in pathogenic aging phenotypes. Many bat species have exceptional longevity given their body size and some can live up to ten times longer than expected with little signs of aging. This study explores the anal microbiome of the exceptionally long-lived Myotis myotis bat, investigating bacterial composition in both adult and juvenile bats to determine if the microbiome changes with age in a wild, long-lived non-model organism, using non-lethal sampling. The anal microbiome was sequenced using metabarcoding in more than 50 individuals, finding no significant difference between the composition of juvenile and adult bats, suggesting that age-related microbial shifts previously observed in other mammals may not be present in Myotis myotis. Functional gene categories, inferred from metabarcoding data, expressed in the M. myotis microbiome were categorized identifying pathways involved in metabolism, DNA repair and oxidative phosphorylation. We highlight an abundance of 'Proteobacteria' relative to other mammals, with similar patterns compared to other bat microbiomes. Our results suggest that M. myotis may have a relatively stable, unchanging microbiome playing a role in their extended 'health spans' with the advancement of age, and suggest a potential link between microbiome and sustained, powered flight. en
dc.description.sponsorship University College Dublin (Seed funding grant); Conseil Régional de Bretagne (Contrat Nature (‘Etude de la dynamique des populations de grand murin (Myotis myotis) en Bretagne et Pays de Loire’) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher PeerJ Inc. en
dc.relation.uri https://peerj.com/articles/4174/
dc.rights © 2018, Hughes et al. Distributed under Creative Commons CC-BY 4.0 https://creativecommons.org/licenses/by/4.0/ en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Gut microbiota en
dc.subject Host phylogeny en
dc.subject Bats en
dc.subject Conservation en
dc.subject Communities en
dc.subject Information en
dc.subject Evolution en
dc.subject Geography en
dc.subject Flight en
dc.subject Fuel en
dc.title Is there a link between aging and microbiome diversity in exceptional mammalian longevity? en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John Leech, APC Microbiome Institute, University College Cork, Cork, Ireland. +353-21-490-3000 Email: john.leech@teagasc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.wokid WOS:000417880400017
dc.contributor.funder Conseil Régional de Bretagne
dc.contributor.funder University College Dublin
dc.contributor.funder European Research Council
dc.description.status Peer reviewed en
dc.identifier.journaltitle PeerJ en
dc.internal.IRISemailaddress john.leech@teagasc.ie en
dc.identifier.articleid e4174
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP2::ERC/311000/EU/Comparative genomics / ‘wildlife’ transcriptomics uncovers the mechanisms of halted ageing in mammals/AGELESS


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© 2018, Hughes et al. Distributed under Creative Commons CC-BY 4.0 https://creativecommons.org/licenses/by/4.0/ Except where otherwise noted, this item's license is described as © 2018, Hughes et al. Distributed under Creative Commons CC-BY 4.0 https://creativecommons.org/licenses/by/4.0/
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