Shining a light on intestinal traffic

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dc.contributor.author Murphy, Carola T.
dc.contributor.author Nally, Kenneth
dc.contributor.author Shanahan, Fergus
dc.contributor.author Melgar, Silvia
dc.contributor.editor McCafferty, Donna-Marie
dc.date.accessioned 2012-07-18T14:25:00Z
dc.date.available 2012-07-18T14:25:00Z
dc.date.issued 2012-01
dc.identifier.citation Carola T. Murphy, Kenneth Nally, Fergus Shanahan, and Silvia Melgar, “Shining a Light on Intestinal Traffic,” Clinical and Developmental Immunology, vol. 2012, Article ID 808157, 14 pages, 2012. doi:10.1155/2012/808157 en
dc.identifier.volume 2012 en
dc.identifier.startpage 808157 en
dc.identifier.issn 1740-2522
dc.identifier.issn 1740-2530
dc.identifier.uri http://hdl.handle.net/10468/634
dc.identifier.doi 10.1155/2012/808157
dc.description.abstract Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is associated with enhanced leukocyte infiltration to the gut, which is directly linked to the clinical aspects of these disorders. Thus, leukocyte trafficking is a major target for IBD therapy. Past and emerging techniques to study leukocyte trafficking both in vitro and in vivo have expanded our knowledge of the leukocyte migration process and the role of inhibitors. Various strategies have been employed to target chemokine- and integrin-ligand interactions within the multistep adhesion cascade and the S1P/S1PR1 axis in leukocyte migration. Though there is an abundance of preclinical data demonstrating efficacy of leukocyte trafficking inhibitors, many have yet to be confirmed in clinical studies. Vigilance for toxicity and further research is required into this complex and emerging area of IBD therapy. en
dc.description.sponsorship Science Foundation Ireland (02/CE/B124; 07/CE/B1368) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Hindawi Publishing Corporation en
dc.relation.uri http://www.hindawi.com/journals/cdi/2012/808157/
dc.rights Copyright © 2012 Carola T. Murphy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.rights.uri http://creativecommons.org/licenses/by/3.0/ en
dc.subject IBD en
dc.subject Leukocyte infiltration en
dc.subject Leukocyte trafficking inhibitors en
dc.subject.lcsh Inflammatory bowel diseases--Treatment en
dc.subject.lcsh Gastrointestinal system--Diseases en
dc.subject.lcsh Crohn’s disease--Treatment en
dc.subject.lcsh Ulcerative colitis--Treatment en
dc.subject.lcsh Leucocytes en
dc.title Shining a light on intestinal traffic en
dc.type Article (peer-reviewed) en
dc.internal.authorurl http://research.ucc.ie/profiles/C012/knally en
dc.internal.authorurl http://research.ucc.ie/profiles/C012/fshanahan en
dc.internal.authorurl http://research.ucc.ie/profiles/D010/carolamurphy en
dc.internal.authorcontactother Carola Murphy, Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: carola.murphy@ucc.ie en
dc.internal.authorcontactother Kenneth Nally, Medicine Department, University College Cork, Cork, Ireland. E-mail: k.nally@ucc.ie en
dc.internal.authorcontactother Fergus Shanahan, Alimentary Pharmabotic Centre, Biosciences Building, University College Cork, Ireland. E-mail: f.shanahan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2012-07-18T10:46:07Z
dc.description.version Published Version en
dc.internal.rssid 139284394
dc.internal.pmid 22162719
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Higher Education Authority en
dc.contributor.funder European Commission en
dc.contributor.funder GlaxoSmithKline, United Kingdom en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Clinical and Developmental Immunology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress carola.murphy@ucc.ie en


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Copyright © 2012 Carola T. Murphy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as Copyright © 2012 Carola T. Murphy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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