Feeding melancholic microbes: MyNewGut recommendations on diet and mood

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dc.contributor.author Dinan, Timothy G.
dc.contributor.author Stanton, Catherine
dc.contributor.author Long-Smith, Caitriona
dc.contributor.author Kennedy, Paul
dc.contributor.author Cryan, John F.
dc.contributor.author Cowan, Caitlin S. M.
dc.contributor.author Cenit, María Carmen
dc.contributor.author van der Kamp, Jan-Willem
dc.contributor.author Sanz, Yolanda
dc.date.accessioned 2018-12-06T10:20:03Z
dc.date.available 2018-12-06T10:20:03Z
dc.date.issued 2018-11-17
dc.identifier.citation Dinan, T. G., Stanton, C., Long-Smith, C., Kennedy, P., Cryan, J. F., Cowan, C. S. M., Cenit, M. C., van der Kamp, J.-W. and Sanz, Y. (2018) 'Feeding melancholic microbes: MyNewGut recommendations on diet and mood', Clinical Nutrition. doi:10.1016/j.clnu.2018.11.010 en
dc.identifier.issn 0261-5614
dc.identifier.uri http://hdl.handle.net/10468/7177
dc.identifier.doi 10.1016/j.clnu.2018.11.010
dc.description.abstract Summary: Depression is a highly prevalent disorder which exerts a major economic impact in all European countries. The brain-gut-microbiota axis has been described as a new paradigm for advancing understanding and treatment of the disorder. There is now over-whelming evidence to support the fact that gut microbes have a major impact on central neurochemistry and behaviour, especially stress related disorders such as depression. Recent studies indicate that patients with depression have a gut dysbiosis. The reason for this dysbiosis is uncertain. Over recent decades, dietary patterns in Europe and elsewhere have undergone major compositional changes, with increased intakes of red meat, high fat foods, and refined sugars. Individuals who consume a Mediterranean diet have lower rates of depression and a recent study suggests that a Mediterranean diet may have antidepressant properties. Assuming this to be the case, which components of the Mediterranean diet mediate the effects? Highly levels of polyphenols or polyunsaturated fatty acids are obvious candidates. We in the MyNewGut consortium recommend that patients with depression or vulnerability to depression should be encouraged to enhance a plant-based diet with a high content of grains/fibres and fish. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Ltd. en
dc.rights © 2018, Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject MyNewGut en
dc.subject Depression en
dc.subject Gut microbiota en
dc.subject Diet en
dc.subject Dysbiosis en
dc.title Feeding melancholic microbes: MyNewGut recommendations on diet and mood en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ted Dinan, Psychiatry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: t.dinan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-11-17
dc.date.updated 2018-12-06T10:07:08Z
dc.description.version Accepted Version en
dc.internal.rssid 464552813
dc.contributor.funder Seventh Framework Programme en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Clinical Nutrition en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress t.dinan@ucc.ie en
dc.internal.IRISemailaddress caitlin.cowan@ucc.ie en
dc.internal.bibliocheck In press. Check for vol. / issue / page numbers. Amend citation as necessary.
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUT


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© 2018, Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.  This manuscript version is made available under the CC-BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2018, Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
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