A brief guide to studying fear in developing rodents: important considerations and common pitfalls.

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dc.contributor.author Cowan, Caitlin S. M.
dc.contributor.author Richardson, Rick
dc.date.accessioned 2019-02-06T16:07:44Z
dc.date.available 2019-02-06T16:07:44Z
dc.date.issued 2018-04-26
dc.identifier.citation Cowan, C. S. M. and Richardson, R. (2018) 'A Brief Guide to Studying Fear in Developing Rodents: Important Considerations and Common Pitfalls', Current Protocols in Neuroscience, 83(1), e44. doi: 10.1002/cpns.44 en
dc.identifier.volume 83 en
dc.identifier.issued 1 en
dc.identifier.startpage e44 en
dc.identifier.endpage e44 en
dc.identifier.issn 1934-8576
dc.identifier.uri http://hdl.handle.net/10468/7458
dc.identifier.doi 10.1002/cpns.44
dc.description.abstract Development is a time of rapid change that sets the pathway to adult functioning across all aspects of physical and mental health. Developmental studies can therefore offer insight into the unique needs of individuals at different stages of normal development as well as the etiology of various disease states. The aim of this overview is to provide an introduction to the practical implementation of developmental studies in rats and mice, with an emphasis on the study of learned fear. We first discuss how developmental factors may influence experimental outcomes for any study. This is followed by a discussion of methodological issues to consider when conducting studies of developing rodents, highlighting examples from the literature on learned fear. Throughout, we offer some recommendations to guide researchers on best practice in developmental studies. en
dc.description.sponsorship National Health and Medical Research Council (APP1031688) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.relation.uri https://currentprotocols.onlinelibrary.wiley.com/doi/abs/10.1002/cpns.44
dc.rights © 2018 by John Wiley & Sons, Inc. This is the peer reviewed version of the following article: Cowan, C. S. M. and Richardson, R. (2018) 'A Brief Guide to Studying Fear in Developing Rodents: Important Considerations and Common Pitfalls', Current Protocols in Neuroscience, 83(1), pp. e44., which has been published in final form at https://currentprotocols.onlinelibrary.wiley.com/doi/abs/10.1002/cpns.44 en
dc.subject Adolescence en
dc.subject Age‐related changes en
dc.subject Development en
dc.subject Fear extinction en
dc.subject Infancy en
dc.subject Pavlovian fear conditioning en
dc.subject Rodent studies en
dc.title A brief guide to studying fear in developing rodents: important considerations and common pitfalls. en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Caitlin Cowan, Alimentary Pharmabotic Centre (APC), University College Cork, Cork, Ireland. +353-21-490-3000 Email: caitlin.cowan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-04-26
dc.date.updated 2019-02-05T16:21:59Z
dc.description.version Accepted Version en
dc.internal.rssid 472455969
dc.internal.pmid 30040208
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Australian Research Council en
dc.contributor.funder National Health and Medical Research Council en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Current Protocols In Neuroscience en
dc.internal.copyrightchecked No !!CORA en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress caitlin.cowan@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/ARC/Discovery Projects/DP150104835/AU/Discovery Projects - Grant ID: DP150104835/ en


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