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Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis
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Accepted version
Date
2019-04-30
Authors
Barry, Alison
Cronin, Owen
Ryan, Aisling M.
Sweeney, Brian
O'Toole, Orna
O'Halloran, Ken D.
Downer, Eric J.
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Verlag
Published Version
Abstract
The objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health. Study participants cycled for 30 min at 65–75% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health. Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS.
Description
Keywords
Multiple sclerosis , Exercise , Cytokines , Plasma Interleukin-10
Citation
Barry, A., Cronin, O., Ryan, A. M., Sweeney, B., O’Toole, O., O’Halloran, K. D. and Downer, E. J. (2019) 'Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis', Neurological Sciences, doi: 10.1007/s10072-019-03915-2
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Copyright
© Fondazione Società Italiana di Neurologia 2019. This is a post-peer-review, pre-copyedit version of an article published in Neurological Sciences. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10072-019-03915-2