Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis

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Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis

Barry, Alison; Cronin, Owen; Ryan, Aisling M.; Sweeney, Brian; O'Toole, Orna; O'Halloran, Ken D.; Downer, Eric J.
Date: 2019-04-30
Copyright: © Fondazione Società Italiana di Neurologia 2019. This is a post-peer-review, pre-copyedit version of an article published in Neurological Sciences. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10072-019-03915-2
Related: https://link.springer.com/article/10.1007%2Fs10072-019-03915-2
Full text restriction information: Access to this article is restricted until 12 months after publication by request of the publisher
Restriction lift date: 2020-04-30
Citation: Barry, A., Cronin, O., Ryan, A. M., Sweeney, B., O’Toole, O., O’Halloran, K. D. and Downer, E. J. (2019) 'Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis', Neurological Sciences, doi: 10.1007/s10072-019-03915-2
Published Version: 10.1007/s10072-019-03915-2

Abstract:

The objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health. Study participants cycled for 30 min at 65–75% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health. Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS.

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