Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis

Show simple item record Barry, Alison Cronin, Owen Ryan, Aisling M. Sweeney, Brian O'Toole, Orna O'Halloran, Ken D. Downer, Eric J. 2019-06-17T15:23:44Z 2019-06-17T15:23:44Z 2019-04-30
dc.identifier.citation Barry, A., Cronin, O., Ryan, A. M., Sweeney, B., O’Toole, O., O’Halloran, K. D. and Downer, E. J. (2019) 'Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis', Neurological Sciences, doi: 10.1007/s10072-019-03915-2 en
dc.identifier.startpage 1 en
dc.identifier.endpage 4 en
dc.identifier.issn 1590-1874
dc.identifier.doi 10.1007/s10072-019-03915-2 en
dc.description.abstract The objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health. Study participants cycled for 30 min at 65–75% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health. Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS. en
dc.description.sponsorship University College Cork (UCC School of Medicine Translational Research Access Programme; UCC Strategic Research Fund; Department of Physiology, UCC) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Verlag en
dc.rights © Fondazione Società Italiana di Neurologia 2019. This is a post-peer-review, pre-copyedit version of an article published in Neurological Sciences. The final authenticated version is available online at: en
dc.subject Multiple sclerosis en
dc.subject Exercise en
dc.subject Cytokines en
dc.subject Plasma Interleukin-10 en
dc.title Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ken O'Halloran, Physiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en Access to this article is restricted until 12 months after publication by request of the publisher en 2020-04-30 2019-06-17T15:15:23Z
dc.description.version Accepted Version en
dc.internal.rssid 468999981
dc.contributor.funder Physiological Society of Ireland en
dc.contributor.funder University College Cork en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Neurological Sciences en
dc.internal.copyrightchecked No !!CORA!!
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress en

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