Microbiota and neurodevelopmental trajectories: role of maternal and early-life nutrition

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Date
2019-06-24
Authors
Codagnone, Martin G.
Stanton, Catherine
O'Mahony, Siobhain M.
Dinan, Timothy G.
Cryan, John F.
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Karger Publishers
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Abstract
Pregnancy and early life are characterized by marked changes in body microbial composition. Intriguingly, these changes take place simultaneously with neurodevelopmental plasticity, suggesting a complex dialogue between the microbes that inhabit the gastrointestinal tract and the brain. The purpose of this chapter is to describe the natural trajectory of microbiota during pregnancy and early life, as well as review the literature available on its interaction with neurodevelopment. Several lines of evidence show that the gut microbiota interacts with diet, drugs and stress both prenatally and postnatally. Clinical and preclinical studies are illuminating how these disruptions result in different developmental outcomes. Understanding the role of the microbiota in neurodevelopment may lead to novel approaches to the study of the pathophysiology and treatment of neuropsychiatric disorders.
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Keywords
Microbiota , Neuropsychiatry , Gut-brain axis , Brain development , Early life , Stress , Diet , Nutrition
Citation
Codagnone, M. G., Stanton, C., O'Mahony, S. M., Dinan, T. G. and Cryan, J. F. (2019) 'Microbiota and neurodevelopmental trajectories: role of maternal and early-life nutrition', Annals of Nutrition and Metabolism, 74(Supplement 2), pp. 16-27. doi: 10.1159/000499144
Copyright
© 2019, S. Karger AG, Basel. This is the peer-reviewed but unedited manuscript version of the following article: Codagnone, M. G., Stanton, C., O'Mahony, S. M., Dinan, T. G. and Cryan, J. F. (2019) 'Microbiota and neurodevelopmental trajectories: Role of maternal and early-life nutrition', Annals of Nutrition and Metabolism, 74(Supplement 2), pp. 16-27. doi: 10.1159/000499144. The final, published version is available at https://www.karger.com/?doi=10.1159/000499144