Vitamin D in pregnancy: current perspectives and future directions

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dc.contributor.author Kiely, Mairead E.
dc.contributor.author Hemmingway, Andrea
dc.contributor.author O'Callaghan, Karen M.
dc.date.accessioned 2019-08-02T08:34:11Z
dc.date.available 2019-08-02T08:34:11Z
dc.date.issued 2017-05-02
dc.identifier.citation Kiely, M., Hemmingway, A. and O'Callaghan, K. M. (2017) 'Vitamin D in pregnancy: current perspectives and future directions', Therapeutic Advances in Musculoskeletal Disease, 9(6), pp. 145-154. doi: 10.1177/1759720x17706453 en
dc.identifier.volume 9 en
dc.identifier.issued 6 en
dc.identifier.startpage 145 en
dc.identifier.endpage 154 en
dc.identifier.issn 1759-720X
dc.identifier.issn 1759-7218
dc.identifier.uri http://hdl.handle.net/10468/8281
dc.identifier.doi 10.1177/1759720x17706453 en
dc.description.abstract As neonatal vitamin D status is determined by circulating maternal 25-hydroxyvitamin D [25(OH)D] concentrations, prevention of maternal vitamin D deficiency during pregnancy is essential for the avoidance of neonatal deficiency. However, a high prevalence of vitamin D deficiency has been extensively reported among gravidae and neonates from ethnic minorities and white populations resident at high latitude. Currently, regulatory authorities recommend vitamin D intakes for pregnant women that are similar to non-pregnant adults of the same age, at 10–15 µg/day (400–600 IU), to meet 25(OH)D thresholds of 25–50 nmol/liter. The lack of pregnancy-specific dietary recommendations is due to inadequate data indicating whether nutritional requirements for vitamin D during pregnancy differ from the non-pregnant state. In addition, there are few dose–response studies to determine the maternal 25(OH)D response to vitamin D intake throughout pregnancy at high latitude. These data are also required to determine vitamin D requirements during pregnancy for prevention of neonatal deficiency, an outcome which is likely to require a higher maternal 25(OH)D concentration than prevention of maternal deficiency only. With regard to the impact of vitamin D on perinatal health outcomes, which could guide pregnancy-specific 25(OH)D thresholds, dietary intervention studies to date have been inconsistent and recent systematic reviews have highlighted issues of low quality and a high risk of bias as drawbacks in the trial evidence to date. Many observational studies have been hampered by a reliance on retrospective data, unclear reporting, suboptimal clinical phenotyping and incomplete subject characterization. Current investigations of vitamin D metabolism during pregnancy have potentially exciting implications for clinical research. This paper provides an update of current dietary recommendations for vitamin D in pregnant women and a synopsis of the evidence relating vitamin D status with maternal and infant health. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher SAGE Publications en
dc.relation.uri https://journals.sagepub.com/doi/abs/10.1177/1759720X17706453
dc.rights © 2017, the Authors. Published by SAGE publications. All rights reserved. en
dc.subject Vitamin D and pregnant women en
dc.subject Vitamin D requirements en
dc.subject Neonatal vitamin D status en
dc.title Vitamin D in pregnancy: current perspectives and future directions en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Andrea Hemmingway, Infant Research Centre, University College Cork, Cork, Ireland. +353-21-490-3000 Email: andrea.hemmingway@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2019-08-01T11:55:01Z
dc.description.version Accepted Version en
dc.internal.rssid 495001033
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Seventh Framework Programme en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Therapeutic Advances in Musculoskeletal Disease en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress andrea.hemmingway@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Spokes Programme/14/SP APC INFANT/B3067/IE/The Cork Nutrition and Microbiome Maternal-Infant Cohort Study (COMBINE)/ en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODIN en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/ en


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