• Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease 

  Ryan, Fergal J.; Ahern, A. M.; Fitzgerald, R. S.; Laserna-Mendieta, E. J.; Power, E. M.; Clooney, A. G.; O'Donoghue, K. W.; McMurdie, P. J.; Iwai, S.; Crits-Christoph, A.; Sheehan, F.; Moran, C.; Flemer, B.; Zomer, A. L.; Fanning, A.; O'Callaghan, J.; Walton, Janette; Temko, Andriy; Stack, W.; Jackson, L.; Joyce, Susan A.; Melgar, Silvia; DeSantis, Todd Z.; Bell, Bell, Jordana T.; Shanahan, Fergus; Claesson, Marcus J. (Springer Nature, 2020-03-23)

  Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed and ...
• Mutagenesis by microbe: The role of the microbiota in shaping the cancer genome 

  Barrett, Maurice; Hand, Collette K.; Shanahan, Fergus; Murphy, Thomas; O'Toole, Paul W. (Elsevier Inc., 2020-02-20)

  Cancers arise through the process of somatic evolution fueled by the inception of somatic mutations. We lack a complete understanding of the sources of these somatic mutations. Humans host a vast repertoire of microbes ...
• European position paper on rhinosinusitis and nasal polyps 2020 

  Fokkens, Wytske J.; Lund, Valerie J.; Hopkins, Claire; Hellings, Peter W.; Kern, Robert; Reitsma, Sietze; Toppila-Salmi, Sanna; Bernal-Sprekelsen, Manuel; Mullol, Joaquim; Alobid, Isam; Anselmo-Lima, Wilma Terezinha; Bachert, Claus; Baroody, Fuad; von Buchwald, Christian; Cervin, Anders; Cohen, Noam; Constantinidis, Jannis; De Gabory, Ludovic; Desrosiers, Martin; Diamant, Zuzana; Douglas, Richard G.; Gevaert, Philippe H.; Hafner, Anita; Harvey, Richard J.; Joos, Guy F.; Kalogjera, Livije; Knill, Andrew; Kocks, Janwillem H.; Landis, Basile N.; Limpens, Jacqueline; Lebeer, Sarah; Lourenco, Olga; Matricardi, Paolo M.; Meco, Cem; O’Mahony, Liam (International and European Rhinologic Societies, 2020-02)

  The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide ...
• Palliative care needs in Parkinson’s disease: focus on anticipatory grief in family carers 

  Fox, Siobhán; Azman, Atheerah; Timmons, Suzanne (AME Publishing Company, 2020-02)

  Methods: Family carers of people with moderate to advanced PD (Hoehn & Yahr stages 3-5) were invited to complete a survey, including demographic questions and three questionnaires: Zarit Burden Interview (ZBI); 16-item ...
• Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma 

  Agache, Ioana; Beltran, Jessica; Akdis, Cezmi; Akdis, Mubeccel; Canelo-Aybar, Carlos; Canonica, Walter; Casale, Thomas; Chivato, Tomas; Corren, Jonathan; Del Giacco, Stefano; Eiwegger, Thomas; Firinu, Davide; Gern, James E.; Hamelmann, Eckard; Hanania, Nicola; Mäkelä, Mika; Martín, Irene Hernández; Nair, Parameswaran; O'Mahony, Liam; Papadopoulos, Nikolaos G.; Papi, Alberto; Park, Hae-Sim; Pérez de Llano, Luis; Posso, Margarita; Rocha, Claudio; Quirce, Santiago; Sastre, Joaquin; Shamji, Mohamed; Song, Yang; Steiner, Corinna; Schwarze, Jurgen; Alonso-Coello, Pablo; Palomares, Oscar; Jutel, Marek (John Wiley & Sons, Inc., 2020-02-08)

  Five biologicals have been approved for severe eosinophilic asthma, a well-recognised phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab ...

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