• Entinostat decreases immune suppression to promote antitumor responses in a HER2+ breast tumor microenvironment 

  Sidiropoulos, Dimitrios N.; Rafie, Christine I.; Jang, Julie K.; Castanon, Sofi; Baugh, Aaron G.; Gonzalez, Edgar; Christmas, Brian J.; Narumi, Valerie H.; Davis-Marcisak, Emily F.; Sharma, Gaurav; Bigelow, Emma; Vaghasia, Ajay; Gupta, Anuj; Skaist, Alyza; Considine, Michael; Wheelan, Sarah J.; Kumar Ganesan, Sathish; Yu, Min; Yegnasubramanian, Srinivasan; Stearns, Vered; Connolly, Roisin M.; Gaykalova, Daria A.; Kagohara, Luciane T.; Jaffee, Elizabeth M.; Fertig, Elana J.; Roussos Torres, Evanthia T. (American Association for Cancer Research, 2022-05-03)

  Therapeutic combinations to alter immunosuppressive, solid tumor microenvironments (TME), such as in breast cancer, are essential to improve responses to immune checkpoint inhibitors (ICI). Entinostat, an oral histone ...
• Association between social deprivation and incidence of first seizures and epilepsy: A prospective population-based cohort 

  Maloney, Eimer M.; Corcoran, Paul; Costello, Daniel J.; O'Reilly, Éilis J. (John Wiley & Sons, Inc., 2022-05-25)

  Objective: Epidemiologic studies have investigated whether social deprivation is associated with a higher incidence of epilepsy, and results are conflicting, especially in children. The mechanisms underlying a potential ...
• Effect of the α4β7 integrin blocking antibody vedolizumab on the clinical and host immune response in patients with inflammatory bowel disease 

  Judge, Ciaran (University College Cork, 2022-02-05)

  Background: Inflammatory bowel disease (IBD) is a chronic, relapsing and remitting condition affecting the gastrointestinal tract. Development of IBD is thought to arise from a complex interplay of genetic susceptibility, ...
• Study of methods, systems, recommendations and bereaved parents’ involvements in perinatal death reviews, inquiries and audits 

  Helps, Änne (University College Cork, 2021-12-10)

  Background: An estimated 5.3 million perinatal deaths occur worldwide each year. In Ireland, there were 335 perinatal deaths reported in 2019. These deaths are devastating for the parents, families and, if unexpected, ...
• Investigating the utility of blood borne oncological biomarkers in solid tumours: glioma and melanoma 

  Ita, Michael Itak (University College Cork, 2021-07-15)

  Bloodborne molecular biomarkers are increasingly emerging as significant non-invasive adjuncts to current methods of disease status evaluation in cancer patients. Investigations into the potential utility of these circulating ...

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