Monocyte mobilisation, microbiota & mental illness

Show simple item record

dc.contributor.author van de Wouw, Marcel
dc.contributor.author Boehme, Marcus
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.date.accessioned 2019-09-19T09:48:58Z
dc.date.available 2019-09-19T09:48:58Z
dc.date.issued 2019-07-19
dc.identifier.citation van de Wouw, M., Boehme, M., Dinan, T. G. and Cryan, J. F. (2019) 'Monocyte mobilisation, microbiota & mental illness', Brain, Behavior, and Immunity, 81, pp. 74-91. doi: 10.1016/j.bbi.2019.07.019 en
dc.identifier.volume 81 en
dc.identifier.startpage 74 en
dc.identifier.endpage 91 en
dc.identifier.issn 0889-1591
dc.identifier.uri http://hdl.handle.net/10468/8570
dc.identifier.doi 10.1016/j.bbi.2019.07.019 en
dc.description.abstract The gastrointestinal microbiome has emerged as a key player in regulating brain and behaviour. This has led to the strategy of targeting the gut microbiota to ameliorate disorders of the central nervous system. Understanding the underlying signalling pathways in which the microbiota impacts these disorders is crucial for the development of future therapeutics for improving CNS functionality. One of the major pathways through which the microbiota influences the brain is the immune system, where there is an increasing appreciation for the role of monocyte trafficking in regulating brain homeostasis. In this review, we will shed light on the role of monocyte trafficking as a relay of microbiota signals in conditions where the central nervous system is in disorder, such as stress, peripheral inflammation, ageing, traumatic brain injury, stroke, multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. We also cover how the gastrointestinal microbiota is implicated in these mental illnesses. In addition, we aim to discuss how the monocyte system can be modulated by the gut microbiota to mitigate disorders of the central nervous system, which will lead to novel microbiota-targeted strategies. en
dc.description.sponsorship Science Foundation Ireland (SFI Grant AMBROSIAC (15/JP‐HDHL/3270)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S0889159119306075
dc.rights © 2019, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 licence. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Microbiota en
dc.subject Monocytes en
dc.subject Brain en
dc.subject Behaviour en
dc.subject Immune system en
dc.subject Stress en
dc.subject Ageing en
dc.subject Traumatic brain injury en
dc.subject Stroke en
dc.subject Neurodegeneration en
dc.title Monocyte mobilisation, microbiota & mental illness en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John F Cryan, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.cryan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-07-19
dc.date.updated 2019-09-19T09:39:28Z
dc.description.version Accepted Version en
dc.internal.rssid 499775495
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Brain, Behavior, and Immunity en
dc.internal.copyrightchecked No
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress j.cryan@ucc.ie en
dc.internal.IRISemailaddress marcel.vandewouw@ucc.ie en
dc.internal.IRISemailaddress marcus.boehme@ucc.ie en
dc.internal.IRISemailaddress t.dinan@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en


Files in this item

This item appears in the following Collection(s)

Show simple item record

© 2019, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 licence. Except where otherwise noted, this item's license is described as © 2019, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 licence.
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement