Monocyte mobilisation, microbiota & mental illness
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Accepted version
Date
2019-07-19
Authors
van de Wouw, Marcel
Boehme, Marcus
Dinan, Timothy G.
Cryan, John F.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Published Version
Abstract
The gastrointestinal microbiome has emerged as a key player in regulating brain and behaviour. This has led to the strategy of targeting the gut microbiota to ameliorate disorders of the central nervous system. Understanding the underlying signalling pathways in which the microbiota impacts these disorders is crucial for the development of future therapeutics for improving CNS functionality. One of the major pathways through which the microbiota influences the brain is the immune system, where there is an increasing appreciation for the role of monocyte trafficking in regulating brain homeostasis. In this review, we will shed light on the role of monocyte trafficking as a relay of microbiota signals in conditions where the central nervous system is in disorder, such as stress, peripheral inflammation, ageing, traumatic brain injury, stroke, multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. We also cover how the gastrointestinal microbiota is implicated in these mental illnesses. In addition, we aim to discuss how the monocyte system can be modulated by the gut microbiota to mitigate disorders of the central nervous system, which will lead to novel microbiota-targeted strategies.
Description
Keywords
Microbiota , Monocytes , Brain , Behaviour , Immune system , Stress , Ageing , Traumatic brain injury , Stroke , Neurodegeneration
Citation
van de Wouw, M., Boehme, M., Dinan, T. G. and Cryan, J. F. (2019) 'Monocyte mobilisation, microbiota & mental illness', Brain, Behavior, and Immunity, 81, pp. 74-91. doi: 10.1016/j.bbi.2019.07.019