Bifidobacterium and Lactobacillus composition at species level and gut microbiota diversity in infants before 6 weeks

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dc.contributor.author Yang, Bo
dc.contributor.author Chen, Yingqi
dc.contributor.author Stanton, Catherine
dc.contributor.author Ross, R. Paul
dc.contributor.author Lee, Yuan-Kun
dc.contributor.author Zhao, Jianxin
dc.contributor.author Zhang, Hao
dc.contributor.author Chen, Wei
dc.date.accessioned 2019-09-23T09:53:14Z
dc.date.available 2019-09-23T09:53:14Z
dc.date.issued 2019-07-05
dc.identifier.citation Yang, B., Chen, Y., Stanton, C., Ross, R. P., Lee, Y.-K., Zhao, J., Zhang, H. and Chen, W. (2019) 'Bifidobacterium and Lactobacillus Composition at Species Level and Gut Microbiota Diversity in Infants before 6 Weeks', International Journal of Molecular Sciences, 20(13). (16pp.) 3306. DOI: 10.3390/ijms20133306 en
dc.identifier.volume 20 en
dc.identifier.issued 10 en
dc.identifier.startpage 1 en
dc.identifier.endpage 16 en
dc.identifier.issn 1661-6596
dc.identifier.uri http://hdl.handle.net/10468/8591
dc.identifier.doi 10.3390/ijms20133306 en
dc.description.abstract Our objective was to investigate the effects of different delivery and feeding modes on the gut microbiota composition of early infants with special emphasis on Bifidobacterium and Lactobacillus profiles at species level. 16S rRNA V3-V4 regions, bifidobacterial, and lactobacilli groEL genes from infant feces were sequenced by Illumina MiSeq. Gut microbiota abundance was significantly different, where standard vaginally delivered (SVD) and breast-fed (BF) groups were higher in comparison with caesarean section (CS), milk-powder-fed (MPF), and mixed-fed (MF) groups. The genus unclassified Enterobacteriaceae was dominant, followed by Bifidobacterium, which was highly abundant in SVD and BF groups. The dominant Bifidobacterium species in all groups were B. longum subsp. longum, B. longum subsp. infantis and B. animalis subsp. lactis. B. dentium and the diversity of Bifidobacterium in SVD and BF groups were significantly higher. For Lactobacillus profiles, L. rhamnosus and L. gasseri were dominant among all the groups, while Lactobacillus species in CS and MPF groups were more diverse. Functional predictions showed significant differences between delivery mode and feeding groups, such as phosphotransferase system as well as taurine and hypotaurine metabolism. In early infants with different delivery and feeding methods, gut microbiota—particularly bifidobacteria and lactobacilli communities—showed significant differences, with strong implications for physiological functions. en
dc.description.sponsorship National Natural Science Foundation of China (Nos. 31771953, 31820103010); National First-Class Discipline Program of Food Science and Technology (JUFSTR20180102); en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI AG en
dc.relation.uri https://www.mdpi.com/1422-0067/20/13/3306/htm
dc.rights ©2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Gut microbiota en
dc.subject Bifidobacterium communities en
dc.subject Lactobacillus communities en
dc.subject Diversity en
dc.subject Infants en
dc.subject Functional prediction en
dc.title Bifidobacterium and Lactobacillus composition at species level and gut microbiota diversity in infants before 6 weeks en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Paul Ross, APC Microbiome Ireland, University College Cork, Cork, Ireland. +353-21-490-3000 Email: p.ross@ucc.ie. en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder National Natural Science Foundation of China en
dc.contributor.funder Chinese Institute of Food Science and Technology-Scitop Bio-Tech Funding program en
dc.contributor.funder Collaborative innovation center of food safety and quality control in Jiangsu Province en
dc.contributor.funder National First-Class Discipline Program of Food Science and Technology en
dc.description.status Peer reviewed en
dc.identifier.journaltitle International Journal of Molecular Sciences en
dc.internal.IRISemailaddress p.ross@ucc.ie. en
dc.identifier.articleid 3306 en
dc.identifier.eissn 1422-0067


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©2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Except where otherwise noted, this item's license is described as ©2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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