The microbiota of the mother at birth and its influence on the emerging infant oral microbiota from birth to 1 year of age: a cohort study

Hurley, Eimear; Mullins, David; Barrett, Maurice P. J.; O'Shea, Carol Anne; Kinirons, Martin; Ryan, C. Anthony; Stanton, Catherine; Whelton, Helen; Harris, Hugh M. B.; O'Toole, Paul W.

The microbiota of the mother at birth and its influence on the emerging infant oral microbiota from birth to 1 year of age: a cohort study

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Published version

Date

2019-04-26

Authors

Hurley, Eimear

Mullins, David

Barrett, Maurice P. J.

O'Shea, Carol Anne

Kinirons, Martin

Ryan, C. Anthony

Stanton, Catherine

Whelton, Helen

Harris, Hugh M. B.

O'Toole, Paul W.

Publisher

Taylor and Francis Ltd.

Published Version

10.1080/20002297.2019.1599652

Abstract

Background: The acquisition of microbial communities and the influence of delivery mode on the oral microbiota of the newborn infant remains poorly characterised. Methods: A cohort of pregnant women were enrolled in the study (n = 84). All infants were born full term, by Spontaneous vaginal delivery (SVD) or by Caesarean section (CS). At delivery a saliva sample along with a vaginal/skin sample from the mother. Saliva samples were the taken from the infant within one week of birth, and at week 4, week 8, 6 months and 1 year of age. We used high-throughput sequencing of V4-V5 region 16S rRNA amplicons to compare the microbiota of all samples. Results: The vaginal microbiota had a lower alpha diversity than the skin microbiota of the mother, while the infant oral microbiota diversity remained relatively stable from birth to 8 weeks of age. The oral microbiota of the neonate differed by birth modality up to 1 week of age (p < 0.05), but birth modality did not have any influence on the infant oral microbiota beyond this age. Conclusions: We conclude thatbirth mode does not have an effect on the infant oral microbiota beyond 4 weeks of age, and the oral microbiota of infants continues to develop until 1 year of age.

Keywords

Microbiota , Vagina , Skin , Mother , Transmission , Oral cavity , Saliva , Newborn , Infant

Citation

Hurley, E., Mullins, D., Barrett, M.P., O’Shea, C.A., Kinirons, M., Ryan, C.A., Stanton, C., Whelton, H., Harris, H.M. and O’Toole, P.W., 2019. The microbiota of the mother at birth and its influence on the emerging infant oral microbiota from birth to 1 year of age: a cohort study. Journal of Oral Microbiology, 11(1), (1599652). DOI:10.1080/20002297.2019.1599652