Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe

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Ryan, Paul M.
Stolte, Ellen H.
London, Lis E. E.
Wells, Jerry M.
Long, Sarah L.
Joyce, Susan A.
Gahan, Cormac G. M.
Fitzgerald, Gerald F.
Ross, R. Paul
Caplice, Noel M.
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Lactobacillus mucosae DPC 6426 has previously demonstrated potentially cardio-protective properties, in the form of dyslipidaemia and hypercholesterolemia correction in an apolipoprotein-E deficient mouse model. This study aims to characterise the manner in which this microbe may modulate host bile pool composition and immune response, in the context of cardiovascular disease. Lactobacillus mucosae DPC 6426 was assessed for bile salt hydrolase activity and specificity. The microbe was compared against several other enteric strains of the same species, as well as a confirmed bile salt hydrolase-active strain, Lactobacillus reuteri APC 2587.
Exopolysaccharide , Bile acid , Bile salt hydrolase (BSH) , Hypercholesterolaemia , CVD
Ryan, P.M., Stolte, E.H., London, L.E., Wells, J.M., Long, S.L., Joyce, S.A., Gahan, C.G., Fitzgerald, G.F., Ross, R.P., Caplice, N.M. and Stanton, C. (2019) 'Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe'. BMC microbiology, 19(1), 33. (13 pp.). DOI:10.1186/s12866-019-1403-0