Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis

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dc.contributor.author Gheorghe, Cassandra Elise
dc.contributor.author Martin, Jason A.
dc.contributor.author Villalobos Manriquez, Francisca
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.contributor.author Clarke, Gerard
dc.date.accessioned 2019-11-27T09:52:02Z
dc.date.available 2019-11-27T09:52:02Z
dc.date.issued 2019-10-14
dc.identifier.citation Gheorghe, C. E., Martin, J. A., Villalobos Manriquez, F., Dinan, T. G., Cryan, J. F. and Clarke, G. (2019) 'Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis', Current Opinion in Pharmacology, 48, pp. 137-145. doi: 10.1016/j.coph.2019.08.004 en
dc.identifier.volume 48 en
dc.identifier.startpage 137 en
dc.identifier.endpage 145 en
dc.identifier.issn 1471-4892
dc.identifier.uri http://hdl.handle.net/10468/9260
dc.identifier.doi 10.1016/j.coph.2019.08.004 en
dc.description.abstract The gut-brain axis is a bidirectional communication system between the central nervous system and the gastrointestinal tract, in which serotonin (5-HT) functions as a key neurotransmitter. Recent research has increasingly concentrated on tryptophan, the precursor to 5-HT and on the microbial regulation of tryptophan metabolism, with an emphasis on host-microbe control over kynurenine pathway metabolism and microbial-specific pathways that generate bioactive tryptophan metabolites. Here, we critically assess recent progress made towards a mechanistic understanding of the microbial regulation of tryptophan metabolism and microbiota-gut-brain axis homeostasis highlighting the role tryptophan metabolism plays in preclinical and clinical neuroscience and in the challenge to improve our understanding of how perturbed tryptophan metabolism contributes to stress-related psychiatric disorders. en
dc.description.sponsorship Health Research Board (Grant number ILP-POR-2017-013); Air Force Office of Scientific Research (Grant number FA9550-17-1-006) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Ltd. en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S1471489218301279
dc.rights © 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Gut-brain axis en
dc.subject Central nervous system en
dc.subject Gastrointestinal tract en
dc.subject Serotonin en
dc.subject 5-HT en
dc.subject Tryptophan metabolism en
dc.title Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gerard Clarke, Psychiatry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: g.clarke@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-10-14
dc.date.updated 2019-11-27T09:43:11Z
dc.description.version Accepted Version en
dc.internal.rssid 499917494
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder Air Force Office of Scientific Research en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Current Opinion in Pharmacology en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress g.clarke@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.identifier.eissn 1471-4973


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© 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.
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