The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation
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Accepted Version
Date
2011-01
Authors
Eccles, Kevin S.
Deasy, Rebecca E.
Fábián, László
Maguire, Anita R.
Lawrence, Simon E.
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Published Version
Abstract
Absolute stereochemistry of oils and viscous liquids can be
difficult to determine. Co-crystallization involves
generating a crystalline material consisting of more than
one neutral compound. The combination of cocrystallization
with both X-ray diffraction and chiral HPLC
was particularly powerful in overcoming these difficulties
for a series of chiral 3-arylbutanoic acids. Cocrystallization
offers advantages over salt formation
because co-crystals dissociate in solution, meaning
identical HPLC conditions can be used for both the
materials of interest and their co-crystals.
Description
Keywords
Stereochemistry , Co-crystallization , X-ray diffraction , Chiral HPLC
Citation
Eccles, Kevin S., Deasy,Rebecca E., Fabian, Laszlo, Maguire, Anita R., Lawrence, Simon E. (2011) 'The Use of Co-crystals for the Determination of Absolute Stereochemistry: An Alternative to Salt Formation'. Journal of Organic Chemistry, 76 (4):1159-1162. http://pubs.acs.org/doi/abs/10.1021/jo102148p
Copyright
© 2011, American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/jo102148p