The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation

Show simple item record Eccles, Kevin S. Deasy, Rebecca E. Fábián, László Maguire, Anita R. Lawrence, Simon E. 2013-01-30T11:12:12Z 2013-01-30T11:12:12Z 2011-01 2011-01
dc.identifier.citation Eccles, Kevin S., Deasy,Rebecca E., Fabian, Laszlo, Maguire, Anita R., Lawrence, Simon E. (2011) 'The Use of Co-crystals for the Determination of Absolute Stereochemistry: An Alternative to Salt Formation'. Journal of Organic Chemistry, 76 (4):1159-1162. en
dc.identifier.volume 76 en
dc.identifier.issued 4 en
dc.identifier.startpage 1159 en
dc.identifier.endpage 1162 en
dc.identifier.issn 0022-3263
dc.identifier.doi 10.1021/jo102148p
dc.description.abstract Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of cocrystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Cocrystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals. en
dc.description.sponsorship Science Foundation Ireland (08/RFP/MTR1664); Science Foundation Ireland (07/SRC/B1158); Science Foundation Ireland (05/PICA/B802); Science Foundation Ireland (TIDA 09); Science Foundation Ireland (05/PICA/B802/EC07) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Chemical Society en
dc.rights © 2011, American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see en
dc.subject Stereochemistry en
dc.subject Co-crystallization en
dc.subject X-ray diffraction en
dc.subject Chiral HPLC en
dc.subject.lcsh Crystallization en
dc.title The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation en
dc.type Article (peer-reviewed) en
dc.internal.authorurl en
dc.internal.authorcontactother Simon Lawrence, Chemistry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en 2012-12-21T09:27:35Z
dc.description.version Accepted Version en
dc.internal.rssid 117321865
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Irish Research Council for Science Engineering and Technology en
dc.contributor.funder Eli Lilly and Company, United States en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Organic Chemistry en
dc.internal.copyrightchecked Accepted Version - Include set statement. en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress en

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