Mutagenesis by microbe: The role of the microbiota in shaping the cancer genome
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Accepted Version
Date
2020-02-20
Authors
Barrett, Maurice P. J.
Hand, Collette K.
Shanahan, Fergus
Murphy, Thomas
O'Toole, Paul W.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Inc.
Published Version
Abstract
Cancers arise through the process of somatic evolution fueled by the inception of somatic mutations. We lack a complete understanding of the sources of these somatic mutations. Humans host a vast repertoire of microbes collectively known as the microbiota. The microbiota plays a role in altering the tumor microenvironment and proliferation. In addition, microbes have been shown to elicit DNA damage which provides the driver for somatic mutations. An understanding of microbiota-driven mutational mechanisms would contribute to a more complete understanding of the origins of the cancer genome. Here, we review the modes by which microbes stimulate DNA damage and the effect of these phenomena upon the cancer genomic architecture, specifically in the form of mutational spectra and mutational signatures.
Description
Keywords
Microbiota , Microbiome , DNA damage , Mutational mechanism , Mutational signatures
Citation
Barrett, M., Hand, C. K., Shanahan, F., Murphy, T. and O'Toole, P. W. (2020) 'Mutagenesis by microbe: The role of the microbiota in shaping the cancer genome', Trends in Cancer, 6(4), 277-287. doi: 10.1016/j.trecan.2020.01.019