Acute stress increases monocyte levels and modulates receptor expression in healthy females
dc.contributor.author | van de Wouw, Marcel | |
dc.contributor.author | Sichetti, Marzia | |
dc.contributor.author | Long-Smith, Caitriona M. | |
dc.contributor.author | Ritz, Nathaniel L. | |
dc.contributor.author | Moloney, Gerard M. | |
dc.contributor.author | Cusack, Anne-Marie | |
dc.contributor.author | Berding, Kirsten | |
dc.contributor.author | Dinan, Timothy G. | |
dc.contributor.author | Cryan, John F. | |
dc.contributor.funder | Seventh Framework Programme | en |
dc.contributor.funder | Science Foundation Ireland | en |
dc.date.accessioned | 2022-03-25T15:11:10Z | |
dc.date.available | 2022-03-25T15:11:10Z | |
dc.date.issued | 2021-05 | |
dc.date.updated | 2022-03-25T14:53:54Z | |
dc.description.abstract | There has been a growing recognition of the involvement of the immune system in stress-related disorders. Acute stress leads to the activation of neuroendocrine systems, which in turn orchestrate a large-scale redistribution of innate immune cells, such as monocytes. Even though acute stress/monocyte interactions have been wellcharacterized in mice, this is not the case for humans. As such, this study aimed to investigate whether acute stress modulates blood monocyte levels in a subtype-dependent manner and whether the receptor expression of stress-related receptors is affected in humans. Blood was collected from healthy female volunteers at baseline and 1 h after the socially evaluated cold pressor test, after which blood monocyte levels and receptor expression were assessed by flow cytometry. Our results reveal a stress-induced increase in blood monocyte levels, which was independent of monocyte subtypes. Furthermore, colony stimulating factor 1 receptor (CSF-1R) and CD29 receptor expression was increased, while CD62L showed a trend towards increased expression. These results provide novel insights into how acute stress affects the innate immune system. | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Published Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | van de Wouw, M., Sichetti, M., Long-Smith, C. M., Ritz, N. L., Moloney, G. M., Cusack, A-M., Berding, K., Dinan, T. G. and Cryan, J. F. (2021) 'Acute stress increases monocyte levels and modulates receptor expression in healthy females', Brain Behavior and Immunity, 94, pp. 463-468. doi: 10.1016/j.bbi.2021.03.005 | en |
dc.identifier.doi | 10.1016/j.bbi.2021.03.005 | en |
dc.identifier.endpage | 468 | en |
dc.identifier.issn | 0889-1591 | |
dc.identifier.journaltitle | Brain Behavior and Immunity | en |
dc.identifier.startpage | 463 | en |
dc.identifier.uri | https://hdl.handle.net/10468/12993 | |
dc.identifier.volume | 94 | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.relation.project | info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUT | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ | en |
dc.rights | © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | Psychological stress | en |
dc.subject | Immune cells | en |
dc.subject | Glucocorticoids | en |
dc.subject | Brain | en |
dc.subject | Inflammation | en |
dc.subject | Recruitment | en |
dc.subject | Activation | en |
dc.subject | Depression | en |
dc.subject | Responses | en |
dc.subject | Cortisol | en |
dc.title | Acute stress increases monocyte levels and modulates receptor expression in healthy females | en |
dc.type | Article (peer-reviewed) | en |
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