Acute stress increases monocyte levels and modulates receptor expression in healthy females

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dc.contributor.authorvan de Wouw, Marcel
dc.contributor.authorSichetti, Marzia
dc.contributor.authorLong-Smith, Caitriona M.
dc.contributor.authorRitz, Nathaniel L.
dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorCusack, Anne-Marie
dc.contributor.authorBerding, Kirsten
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2022-03-25T15:11:10Z
dc.date.available2022-03-25T15:11:10Z
dc.date.issued2021-05
dc.date.updated2022-03-25T14:53:54Z
dc.description.abstractThere has been a growing recognition of the involvement of the immune system in stress-related disorders. Acute stress leads to the activation of neuroendocrine systems, which in turn orchestrate a large-scale redistribution of innate immune cells, such as monocytes. Even though acute stress/monocyte interactions have been wellcharacterized in mice, this is not the case for humans. As such, this study aimed to investigate whether acute stress modulates blood monocyte levels in a subtype-dependent manner and whether the receptor expression of stress-related receptors is affected in humans. Blood was collected from healthy female volunteers at baseline and 1 h after the socially evaluated cold pressor test, after which blood monocyte levels and receptor expression were assessed by flow cytometry. Our results reveal a stress-induced increase in blood monocyte levels, which was independent of monocyte subtypes. Furthermore, colony stimulating factor 1 receptor (CSF-1R) and CD29 receptor expression was increased, while CD62L showed a trend towards increased expression. These results provide novel insights into how acute stress affects the innate immune system.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationvan de Wouw, M., Sichetti, M., Long-Smith, C. M., Ritz, N. L., Moloney, G. M., Cusack, A-M., Berding, K., Dinan, T. G. and Cryan, J. F. (2021) 'Acute stress increases monocyte levels and modulates receptor expression in healthy females', Brain Behavior and Immunity, 94, pp. 463-468. doi: 10.1016/j.bbi.2021.03.005en
dc.identifier.doi10.1016/j.bbi.2021.03.005en
dc.identifier.endpage468en
dc.identifier.issn0889-1591
dc.identifier.journaltitleBrain Behavior and Immunityen
dc.identifier.startpage463en
dc.identifier.urihttps://hdl.handle.net/10468/12993
dc.identifier.volume94en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUTen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectPsychological stressen
dc.subjectImmune cellsen
dc.subjectGlucocorticoidsen
dc.subjectBrainen
dc.subjectInflammationen
dc.subjectRecruitmenten
dc.subjectActivationen
dc.subjectDepressionen
dc.subjectResponsesen
dc.subjectCortisolen
dc.titleAcute stress increases monocyte levels and modulates receptor expression in healthy femalesen
dc.typeArticle (peer-reviewed)en
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