dc.contributor.author	Raae Hansen, Christina
dc.contributor.author	O'Mahony, Denis
dc.contributor.author	Kearney, Patricia M.
dc.contributor.author	Sahm, Laura J.
dc.contributor.author	Cullinan, Shane
dc.contributor.author	Huibers, C. J. A.
dc.contributor.author	Thevelin, Stefanie
dc.contributor.author	Rutjes, Anne W. S.
dc.contributor.author	Knol, Wilma
dc.contributor.author	Streit, Sven
dc.contributor.author	Byrne, Stephen
dc.contributor.funder	Horizon 2020	en
dc.contributor.funder	State Secretariat for Education, Research and Innovation, Switzerland
dc.date.accessioned	2018-12-14T09:42:51Z
dc.date.available	2018-12-14T09:42:51Z
dc.date.issued	2018-08-20
dc.date.updated	2018-12-14T09:30:06Z
dc.description.abstract	Aims: Deprescribing interventions safely and effectively optimize medication use in older people. However, questions remain about which components of interventions are key to effectively reduce inappropriate medication use. This systematic review examines the behaviour change techniques (BCTs) of deprescribing interventions and summarizes intervention effectiveness on medication use and inappropriate prescribing. Methods: MEDLINE, EMBASE, Web of Science and Academic Search Complete and grey literature were searched for relevant literature. Randomized controlled trials (RCTs) were included if they reported on interventions in people aged =65 years. The BCT taxonomy was used to identify BCTs frequently observed in deprescribing interventions. Effectiveness of interventions on inappropriate medication use was summarized in meta-analyses. Medication appropriateness was assessed in accordance with STOPP criteria, Beers' criteria and national or local guidelines. Between-study heterogeneity was evaluated by I-squared and Chi-squared statistics. Risk of bias was assessed using the Cochrane Collaboration Tool for randomized controlled studies. Results: Of the 1561 records identified, 25 studies were included in the review. Deprescribing interventions were effective in reducing number of drugs and inappropriate prescribing, but a large heterogeneity in effects was observed. BCT clusters including goals and planning; social support; shaping knowledge; natural consequences; comparison of behaviour; comparison of outcomes; regulation; antecedents; and identity had a positive effect on the effectiveness of interventions. Conclusions: In general, deprescribing interventions effectively reduce medication use and inappropriate prescribing in older people. Successful deprescribing is facilitated by the combination of BCTs involving a range of intervention components.	en
dc.description.sponsorship	State Secretariat for Education, Research and Innovation, Switzerland (Contract Number 15.0137)	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Raae Hansen, C., O'Mahony, D., Kearney, P. M., Sahm, L. J., Cullinan, S., Huibers, C. J. A., Thevelin, S., Rutjes, A. W. S., Knol, W., Streit, S. and Byrne, S. (2018) 'Identification of behaviour change techniques in deprescribing interventions: a systematic review and meta-analysis', British Journal of Clinical Pharmacology, 84(12), pp. 2716-2728. doi:10.1111/bcp.13742	en
dc.identifier.doi	10.1111/bcp.13742
dc.identifier.endpage	2728	en
dc.identifier.issn	0306-5251
dc.identifier.issn	1365-2125
dc.identifier.issued	12	en
dc.identifier.journaltitle	British Journal of Clinical Pharmacology	en
dc.identifier.startpage	2716	en
dc.identifier.uri	https://hdl.handle.net/10468/7222
dc.identifier.volume	84	en
dc.language.iso	en	en
dc.publisher	John Wiley & Sons Ltd.	en
dc.relation.project	info:eu-repo/grantAgreement/EC/H2020::RIA/634238/EU/OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly/OPERAM	en
dc.rights	© 2018, the Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	en
dc.subject	Behaviour change techniques	en
dc.subject	Deprescribing	en
dc.subject	Meta-analysis	en
dc.subject	Systematic review	en
dc.title	Identification of behaviour change techniques in deprescribing interventions: a systematic review and meta-analysis	en
dc.type	Article (peer-reviewed)	en

Identification of behaviour change techniques in deprescribing interventions: a systematic review and meta-analysis

Files

Original bundle

License bundle

Collections