Gut microbiota composition correlates with diet and health in the elderly

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dc.contributor.authorClaesson, Marcus J.
dc.contributor.authorJeffery, Ian B.
dc.contributor.authorConde, Susana
dc.contributor.authorPower, Susan E.
dc.contributor.authorO'Connor, Eibhlí­s M.
dc.contributor.authorCusack, Siobhán
dc.contributor.authorHarris, Hugh M. B.
dc.contributor.authorCoakley, Mairead
dc.contributor.authorLakshminarayanan, Bhuvaneswari
dc.contributor.authorO'Sullivan, Orla
dc.contributor.authorFitzgerald, Gerald F.
dc.contributor.authorDeane, Jennifer
dc.contributor.authorO'Connor, Michael
dc.contributor.authorHarnedy, Norma
dc.contributor.authorO'Connor, Kieran
dc.contributor.authorO'Mahony, Denis
dc.contributor.authorvan Sinderen, Douwe
dc.contributor.authorWallace, Martina
dc.contributor.authorBrennan, Lorraine
dc.contributor.authorStanton, Catherine
dc.contributor.authorMarchesi, Julian R.
dc.contributor.authorFitzgerald, Anthony P.
dc.contributor.authorShanahan, Fergus
dc.contributor.authorHill, Colin
dc.contributor.authorRoss, R. Paul
dc.contributor.authorO'Toole, Paul W.
dc.contributor.funderDepartment of Agriculture, Food and the Marine, Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2020-10-13T11:51:10Z
dc.date.available2020-10-13T11:51:10Z
dc.date.issued2012-07-13
dc.date.updated2020-10-13T11:33:40Z
dc.description.abstractAlterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.en
dc.description.sponsorshipDepartment of Agriculture Food and Marine and Health Research Board (FHRI award to the ELDERMET project); Science Foundation Ireland (Award to the Alimentary Pharmabiotic Centre, University College Cork); Health Research Board (Fellowship)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationClaesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., Fitzgerald, G. F., Deane, J., O’Connor, M., Harnedy, N., O’Connor, K., O’Mahony, D., van Sinderen, D., Wallace, M., Brennan, L., Stanton, C., Marchesi, J. R., Fitzgerald, A. P., Shanahan, F., Hill, C., Ross, R. P. and O’Toole, P. W. (2012) ‘Gut microbiota composition correlates with diet and health in the elderly’, Nature, 488, pp. 178–184. doi: 10.1038/nature11319en
dc.identifier.doi10.1038/nature11319en
dc.identifier.eissn1476-4687
dc.identifier.endpage184en
dc.identifier.issn0028-0836
dc.identifier.journaltitleNatureen
dc.identifier.startpage178en
dc.identifier.urihttps://hdl.handle.net/10468/10653
dc.identifier.volume488en
dc.language.isoenen
dc.publisherMacmillan Publishers Limiteden
dc.rights© 2012, Macmillan Publishers Limited. All rights reserved. This is a post-peer-review, pre-copyedit version of an article published in Nature. The final authenticated version is available online at: https://doi.org/10.1038/nature11319en
dc.subjectFecal microbiotaen
dc.subjectPhylogenetic microarrayen
dc.subjectSequencesen
dc.subjectRegressionen
dc.subjectIntestineen
dc.subjectTaxonomyen
dc.subjectDiseaseen
dc.subjectIndexen
dc.subjectAgeen
dc.titleGut microbiota composition correlates with diet and health in the elderlyen
dc.typeArticle (peer-reviewed)en
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