The Trier Social Stress Test: principles and practice

dc.contributor.authorAllen, Andrew P.
dc.contributor.authorKennedy, Paul J.
dc.contributor.authorDockray, Samantha
dc.contributor.authorCryan, John F.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorClarke, Gerard
dc.contributor.funderHealth Research Boarden
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2017-01-10T11:41:57Z
dc.date.available2017-01-10T11:41:57Z
dc.date.issued2016-11-12
dc.date.updated2017-01-10T11:37:42Z
dc.description.abstractResearchers interested in the neurobiology of the acute stress response in humans require a valid and reliable acute stressor that can be used under experimental conditions. The Trier Social Stress Test (TSST) provides such a testing platform. It induces stress by requiring participants to make an interview-style presentation, followed by a surprise mental arithmetic test, in front of an interview panel who do not provide feedback or encouragement. In this review, we outline the methodology of the TSST, and discuss key findings under conditions of health and stress-related disorder. The TSST has unveiled differences in males and females, as well as different age groups, in their neurobiological response to acute stress. The TSST has also deepened our understanding of how genotype may moderate the cognitive neurobiology of acute stress, and exciting new inroads have been made in understanding epigenetic contributions to the biological regulation of the acute stress response using the TSST. A number of innovative adaptations have been developed which allow for the TSST to be used in group settings, with children, in combination with brain imaging, and with virtual committees. Future applications may incorporate the emerging links between the gut microbiome and the stress response. Future research should also maximise use of behavioural data generated by the TSST. Alternative acute stress paradigms may have utility over the TSST in certain situations, such as those that require repeat testing. Nonetheless, we expect that the TSST remains the gold standard for examining the cognitive neurobiology of acute stress in humans.en
dc.description.sponsorshipHealth Research Board, (HRB) through Health Research Awards (grant number HRA_-POR_2014_647; GC, TGD)); Science Foundation Ireland (SFI grant number SFI/12/RC/2273).en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAllen, A. P., Kennedy, P. J., Dockray, S., Cryan, J. F., Dinan, T. G. and Clarke, G. (2017) 'The Trier Social Stress Test: Principles and practice', Neurobiology of Stress, 6, pp. 113-126. doi:10.1016/j.ynstr.2016.11.001en
dc.identifier.doi10.1016/j.ynstr.2016.11.001
dc.identifier.endpage126
dc.identifier.issn2352-2895
dc.identifier.journaltitleNeurobiology of Stressen
dc.identifier.startpage113
dc.identifier.urihttps://hdl.handle.net/10468/3455
dc.identifier.volume6
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2016, The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectStressen
dc.subjectCognitionen
dc.subjectHPA axisen
dc.subjectEpigeneticsen
dc.subjectGenotypeen
dc.titleThe Trier Social Stress Test: principles and practiceen
dc.typeArticle (peer-reviewed)en
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