Dietary milk phospholipids attenuate chronic stress-induced changes in behavior and endocrine responses across the lifespan

dc.check.date2022-12-17
dc.contributor.authorSchverer, Marina
dc.contributor.authorDonoso, Francisco
dc.contributor.authorMitchell, Avery
dc.contributor.authorRea, Kieran
dc.contributor.authorFitzgerald, Patrick
dc.contributor.authorSen, Paromita
dc.contributor.authorRoy, Bernard L.
dc.contributor.authorStanton, Catherine
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.authorSchellekens, Harriët
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2022-02-17T10:11:38Z
dc.date.available2022-02-17T10:11:38Z
dc.date.issued2021-12-01
dc.description.abstractScope: Increasing scientific evidence is validating the use of dietary strategiesto support and improve brain health throughout the lifespan, with tailorednutritional interventions catering for specific life stages. Dietary phospholipidsupplementations in early life and adulthood are shown to alleviate some ofthe behavioral consequences associated with chronic stress. This study aimsto explore the protective effects of a tailored phospholipid-enriched buttermilkon behavioral and endocrine responses induced by chronic psychosocialstress in adulthood, and to compare these effects according to the life stage atwhich the supplementation is started.Methods and Results: A novel developed phospholipid-enriched dairy productis assessed for its effects on social, anxiety- and depressive-like behaviors, aswell as the stress response and cognitive performance following chronicpsychosocial stress in C57BL/6J mice, with supplementation beginning inadulthood or early life. Milk phospholipid supplementation from birth protectsadult mice against chronic stress-induced changes in endocrine response to asubsequent acute stressor and reduces innate anxiety-like behavior innon-stressed animals. When starting in adulthood, the dietary interventionreverses the anxiety-like phenotype caused by chronic stress exposure.Conclusion: Dairy-derived phospholipids exert differential protective effectsagainst chronic psychosocial stress depending on the targeted life stage andduration of the dietary supplementation.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid2100665en
dc.identifier.citationSchverer, M., Donoso, F., Mitchell, A., Rea, K., Fitzgerald, P., Sen, P., Roy, B. L., Stanton, C., Dinan, T. D., Cryan, J. F. and Schellekens, H. (2021) 'Dietary milk phospholipids attenuate chronic stress-induced changes in behavior and endocrine responses across the lifespan', Molecular Nutrition and Food Research, 66 (2), 2100665 (11pp). doi: 10.1002/mnfr.202100665en
dc.identifier.doi10.1002/mnfr.202100665en
dc.identifier.eissn1613-4133
dc.identifier.endpage11en
dc.identifier.issn1613-4125
dc.identifier.issued2en
dc.identifier.journaltitleMolecular Nutrition and Food Researchen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/12578
dc.identifier.volume66en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2021, Wiley‐VCH GmbH. This is the peer reviewed version of the following article: Schverer, M., Donoso, F., Mitchell, A., Rea, K., Fitzgerald, P., Sen, P., Roy, B. L., Stanton, C., Dinan, T. D., Cryan, J. F. and Schellekens, H. (2021) 'Dietary milk phospholipids attenuate chronic stress-induced changes in behavior and endocrine responses across the lifespan', Molecular Nutrition and Food Research, 66 (2), 2100665 (11pp). doi: 10.1002/mnfr.202100665. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectAnxietyen
dc.subjectChronic stressen
dc.subjectDieten
dc.subjectHypothalamic-pituitary-adrenal axisen
dc.subjectLife stagesen
dc.subjectMilk phospholipidsen
dc.titleDietary milk phospholipids attenuate chronic stress-induced changes in behavior and endocrine responses across the lifespanen
dc.typeArticle (peer-reviewed)en
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