Dietary milk phospholipids attenuate chronic stress-induced changes in behavior and endocrine responses across the lifespan
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Accepted Version
Supplementary Data
Date
2021-12-01
Authors
Schverer, Marina
Donoso, Francisco
Mitchell, Avery
Rea, Kieran
Fitzgerald, Patrick
Sen, Paromita
Roy, Bernard L.
Stanton, Catherine
Dinan, Timothy G.
Cryan, John F.
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley & Sons, Inc.
Published Version
Abstract
Scope: Increasing scientific evidence is validating the use of dietary strategiesto support and improve brain health throughout the lifespan, with tailorednutritional interventions catering for specific life stages. Dietary phospholipidsupplementations in early life and adulthood are shown to alleviate some ofthe behavioral consequences associated with chronic stress. This study aimsto explore the protective effects of a tailored phospholipid-enriched buttermilkon behavioral and endocrine responses induced by chronic psychosocialstress in adulthood, and to compare these effects according to the life stage atwhich the supplementation is started.Methods and Results: A novel developed phospholipid-enriched dairy productis assessed for its effects on social, anxiety- and depressive-like behaviors, aswell as the stress response and cognitive performance following chronicpsychosocial stress in C57BL/6J mice, with supplementation beginning inadulthood or early life. Milk phospholipid supplementation from birth protectsadult mice against chronic stress-induced changes in endocrine response to asubsequent acute stressor and reduces innate anxiety-like behavior innon-stressed animals. When starting in adulthood, the dietary interventionreverses the anxiety-like phenotype caused by chronic stress exposure.Conclusion: Dairy-derived phospholipids exert differential protective effectsagainst chronic psychosocial stress depending on the targeted life stage andduration of the dietary supplementation.
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Keywords
Anxiety , Chronic stress , Diet , Hypothalamic-pituitary-adrenal axis , Life stages , Milk phospholipids
Citation
Schverer, M., Donoso, F., Mitchell, A., Rea, K., Fitzgerald, P., Sen, P., Roy, B. L., Stanton, C., Dinan, T. D., Cryan, J. F. and Schellekens, H. (2021) 'Dietary milk phospholipids attenuate chronic stress-induced changes in behavior and endocrine responses across the lifespan', Molecular Nutrition and Food Research, 66 (2), 2100665 (11pp). doi: 10.1002/mnfr.202100665
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Ā© 2021, WileyāVCH GmbH. This is the peer reviewed version of the following article: Schverer, M., Donoso, F., Mitchell, A., Rea, K., Fitzgerald, P., Sen, P., Roy, B. L., Stanton, C., Dinan, T. D., Cryan, J. F. and Schellekens, H. (2021) 'Dietary milk phospholipids attenuate chronic stress-induced changes in behavior and endocrine responses across the lifespan', Molecular Nutrition and Food Research, 66 (2), 2100665 (11pp). doi: 10.1002/mnfr.202100665. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.