Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse

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dc.contributor.authorScott, Karen A.
dc.contributor.authorIda, Masayuki
dc.contributor.authorPeterson, Veronica L.
dc.contributor.authorPrenderville, Jack A.
dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorIzumo, Takayuki
dc.contributor.authorMurphy, Kiera
dc.contributor.authorMurphy, Amy
dc.contributor.authorRoss, R. Paul
dc.contributor.authorStanton, Catherine
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.contributor.funderMead Johnson Nutritionen
dc.contributor.funderSuntory Wellness Ltd. Japanen
dc.date.accessioned2017-06-02T11:33:19Z
dc.date.available2017-06-02T11:33:19Z
dc.date.issued2017-02-04
dc.date.updated2017-06-02T11:19:21Z
dc.description.abstractOver the last decade, there has been increased interest in the role of the gut microbiome in health including brain health. This is by no means a new theory; Elie Metchnikoff proposed over a century ago that targeting the gut by consuming lactic acid bacteria such as those in yogurt, could improve or delay the onset of cognitive decline associated with ageing. However, there is limited information characterising the relationship between the behavioural and physiological sequelae of ageing and alterations in the gut microbiome. To this end, we assessed the behavioural, physiological and caecal microbiota profile of aged male mice. Older mice (20–21 months old) exhibited deficits in spatial memory and increases in anxiety-like behaviours compared to younger mice (2–3 months old). They also exhibited increased gut permeability, which was directly correlated with elevations in peripheral pro-inflammatory cytokines. Furthermore, stress exacerbated the gut permeability of aged mice. Examination of the caecal microbiota revealed significant increases in phylum TM7, family Porphyromonadaceae and genus Odoribacter of aged mice. This represents a shift of aged microbiota towards a profile previously associated with inflammatory disease, particularly gastrointestinal and liver disorders. Furthermore, Porphyromonadaceae, which has also been associated with cognitive decline and affective disorders, was directly correlated with anxiety-like behaviour in aged mice. These changes suggest that changes in the gut microbiota and associated increases in gut permeability and peripheral inflammation may be important mediators of the impairments in behavioural, affective and cognitive functions seen in ageing.en
dc.description.sponsorshipScience Foundation Ireland (SFI funded research centre, APC Microbiome Institute through the Irish Government’s National Development Plan (Grant Number 12/RC/2273)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationScott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., Dinan, T. G. and Cryan, J. F. (2017) 'Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse', Brain, Behavior, and Immunity, 65, pp. 20-32. doi:10.1016/j.bbi.2017.02.004en
dc.identifier.doi10.1016/j.bbi.2017.02.004
dc.identifier.endpage32
dc.identifier.issn0889-1591
dc.identifier.journaltitleBrain, Behavior, and Immunityen
dc.identifier.startpage20
dc.identifier.urihttps://hdl.handle.net/10468/4046
dc.identifier.volume65
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2017 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 licenseen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMicrobiotaen
dc.subjectMicrobiota-gut-brain axisen
dc.subjectAgeingen
dc.subjectInflammationen
dc.subjectAnxietyen
dc.subjectBehaviouren
dc.subjectCognitive impairmenten
dc.subjectGut permeabilityen
dc.titleRevisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouseen
dc.typeArticle (peer-reviewed)en
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