Low-dose carotid computed tomography angiography using pure iterative reconstruction

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Moloney, Fiachra
Murphy, Kevin P.
Twomey, Maria
Crish, Lee
Canniffe, Emma M.
McLaughlin, Patrick D.
Moore, Niamh
O'Keefe, Michael
O'Neill, Siobhán B.
Manning, Brian M.
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Lippincott, Williams & Wilkins
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The aim of this study was to assess if a low-dose carotid computed tomography angiography (CTA) performed with pure iterative reconstruction (IR) is comparable to a conventional dose CTA protocol. Methods: Twenty patients were included. Radiation dose was divided into a low-dose acquisition reconstructed with pure IR and a conventional dose acquisition reconstructed with 40% hybrid IR. Dose, image noise, contrast resolution, spatial resolution, and carotid artery stenosis were measured. Results: Mean effective dose was significantly lower for low-dose than conventional dose studies (1.84 versus 3.71 mSv; P < 0.001). Subjective image noise, contrast resolution, and spatial resolution were significantly higher for the low-dose studies. There was excellent agreement for stenosis grading accuracy between low- and conventional dose studies (Cohen κ = 0.806). Conclusions: A low-dose carotid CTA protocol reconstructed with pure IR is comparable to a conventional dose CTA protocol in terms of image quality and diagnostic accuracy while enabling a dose reduction of 49.6%.
CT angiography , MBIR , pure iterative reconstruction , Angiography , Carotid artery disease , Multidetector CT , Radiation dose , Stroke , Pure iterative reconstruction
Moloney, F., Murphy, K. P., Twomey, M., Crush, L., Canniffe, E. M., McLaughlin, P. D., Moore, N., O'Keeffe, M., O'Neill, S., Manning, B. M., Wyse, G., Fanning, N., O'Connor, O. J. and Maher, M. M. (2016) 'Low-Dose Carotid Computed Tomography Angiography Using Pure Iterative Reconstruction', Journal of Computer Assisted Tomography, 40(5), pp. 833-839. doi: 10.1097/RCT.0000000000000436
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