Do changing levels of maternal exercise during pregnancy affect neonatal adiposity? Secondary analysis of the babies after SCOPE: evaluating the longitudinal impact using neurological and nutritional endpoints (BASELINE) birth cohort (Cork, Ireland)

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dc.contributor.authorNorris, Tom
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.authorKhashan, Ali S.
dc.contributor.authorMurray, Deirdre M.
dc.contributor.authorKiely, Mairead E.
dc.contributor.authorHourihane, Jonathan O'B.
dc.contributor.authorBaker, Philip N.
dc.contributor.authorKenny, Louise C.
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderFood Standards Agency
dc.contributor.funderNational Children’s Research Centre, Ireland
dc.contributor.funderHealth Research Board
dc.date.accessioned2018-02-06T13:36:30Z
dc.date.available2018-02-06T13:36:30Z
dc.date.issued2017
dc.description.abstractAbstract: Objective To investigate whether changing levels of exercise during pregnancy are related to altered neonatal adiposity. Design: Secondary analysis of data from a prospective cohort study. Setting: Cork, Ireland. Participants: 1200 mother–infant pairs recruited as part of a prospective birth cohort, Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE). Main outcome measures: Neonatal adiposity was assessed within several days of birth using air displacement plethysmography (PEAPOD). Per cent body fat (BF%) as a continuous outcome and a pair of dichotomous variables; high or low adiposity, representing BF% >90th or <10th centile, respectively. Multivariable linear and logistic regression models were used to investigate the relationship between exercise and the respective outcomes. Results: Crude analysis revealed no association between a changing level of exercise (since becoming pregnant) at 15 weeks’ gestation and any of the outcomes (BF%, low adiposity and high adiposity). At 20 weeks’ gestation, analyses revealed that relative to women who do not change their exercise level up to 20 weeks, those women who decreased their exercise level were more likely to give birth to a neonate with adiposity above the 90th centile (OR 1.62, 95% CI 1.07 to 2.46). This association was maintained after adjustment for putative confounders (OR 1.62, 95% CI 1.06 to 2.47). Conclusions: We observed a possible critical period for the association between changing exercise levels and neonatal adiposity, with no association observed with exercise recall for the first 15 weeks of gestation, but an association with a decreasing level of exercise between 15 and 20 weeks. These results should be interpreted in line with the limitations of the study and further studies utilising objectively measured estimates of exercise are required in order to replicate these findings.en
dc.description.sponsorshipHealth Research Board(CSA 2007/2); Food Standards Agency (TO7060)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide017987
dc.identifier.citationNorris, T., McCarthy, F. P., Khashan, A. S., Murray, D. M., Kiely, M., Hourihane, J. O. B., Baker, P. N. and Kenny, L. C. (2017) 'Do changing levels of maternal exercise during pregnancy affect neonatal adiposity? Secondary analysis of the babies after SCOPE: evaluating the longitudinal impact using neurological and nutritional endpoints (BASELINE) birth cohort (Cork, Ireland)', BMJ Open, 7(11), e017987 (100pp). doi: 10.1136/bmjopen-2017-017987en
dc.identifier.doi10.1136/bmjopen-2017-017987
dc.identifier.endpage10
dc.identifier.issued11
dc.identifier.journaltitleBMJ Openen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/5407
dc.identifier.volume7
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/
dc.relation.urihttp://bmjopen.bmj.com/content/7/11/e017987
dc.rights© 2017, the Authors. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercialen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectNeonatal adiposityen
dc.subjectBASELINEen
dc.subjectPregnancyen
dc.titleDo changing levels of maternal exercise during pregnancy affect neonatal adiposity? Secondary analysis of the babies after SCOPE: evaluating the longitudinal impact using neurological and nutritional endpoints (BASELINE) birth cohort (Cork, Ireland)en
dc.typeArticle (peer-reviewed)en
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