Significance of beta-band oscillations in Autism Spectrum Disorders during motor response inhibition tasks: a MEG study

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dc.contributor.authorMoliadze, Vera
dc.contributor.authorBrodski-Guerniero, Alla
dc.contributor.authorSchuetz, Magdalena
dc.contributor.authorSiemann, Julia
dc.contributor.authorLyzhko, Ekaterina
dc.contributor.authorSchlitt, Sabine
dc.contributor.authorKitzerow, Janina
dc.contributor.authorLanger, Anne
dc.contributor.authorKaiser, Jochen
dc.contributor.authorNaumer, Marcus J.
dc.contributor.authorWibral, Michael
dc.contributor.authorChan, Jason S.
dc.contributor.authorFreitag, Christine M.
dc.contributor.authorSiniatchkin, Michael
dc.contributor.funderVolkswagen Foundationen
dc.contributor.funderDeutsche Forschungsgemeinschaften
dc.contributor.funderBundesministerium für Bildung und Forschungen
dc.contributor.funderProjekt DEAL, Germanyen
dc.date.accessioned2020-04-20T09:13:45Z
dc.date.available2020-04-20T09:13:45Z
dc.date.issued2020-04-17
dc.date.updated2020-04-20T09:02:23Z
dc.description.abstractIn Autism Spectrum Disorders (ASD), impaired response inhibition and lack of adaptation are hypothesized to underlie core ASD symptoms, such as social communication and repetitive, stereotyped behavior. Thus, the aim of the present study was to compare neural correlates of inhibition, post-error adaptation, and reaction time variability in ASD and neuro-typical control (NTC) participants by investigating possible differences in error-related changes of oscillatory MEG activity. Twelve male NTC (mean age 20.3 ± 3.7) and fourteen male patients with ASD (mean age 17.8 ± 2.9) were included in the analysis. Subjects with ASD showed increased error-related reaction time variability. MEG analysis revealed decreased beta power in the ASD group in comparison to the NTC group over the centro-parietal channels in both, the pre-stimulus and post-response interval. In the ASD group, mean centro-parietal beta power negatively correlated with dimensional autism symptoms. In both groups, false alarms were followed by an early increase in temporo-frontal theta to alpha power; and by a later decrease in alpha to beta power at central and posterior sensors. Single trial correlations were additionally studied in the ASD group, who showed a positive correlation of pre-stimulus beta power with post-response theta, alpha, and beta power, particularly after hit trials. On a broader scale, the results deliver important insights into top-down control deficits that may relate to core symptoms observed in ASD.en
dc.description.sponsorshipOpen Access funding provided by Projekt DEAL.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMoliadze, V., Brodski-Guerniero, A., Schuetz, M. et al. (2020) ‘Significance of Beta-Band Oscillations in Autism Spectrum Disorders During Motor Response Inhibition Tasks: A MEG Study’, Brain Topography, doi: 10.1007/s10548-020-00765-6en
dc.identifier.doi10.1007/s10548-020-00765-6en
dc.identifier.eissn1573-6792
dc.identifier.endpage20en
dc.identifier.issn0896-0267
dc.identifier.journaltitleBrain Topographyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9838
dc.language.isoenen
dc.publisherSpringeren
dc.rights© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectASDen
dc.subjectMEGen
dc.subjectBeta-band oscillationsen
dc.subjectMotor response inhibitionen
dc.subjectAutism Spectrum Disorders (ASD)en
dc.titleSignificance of beta-band oscillations in Autism Spectrum Disorders during motor response inhibition tasks: a MEG studyen
dc.typeArticle (peer-reviewed)en
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