Significance of beta-band oscillations in Autism Spectrum Disorders during motor response inhibition tasks: a MEG study

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Date
2020-04-17
Authors
Moliadze, Vera
Brodski-Guerniero, Alla
Schuetz, Magdalena
Siemann, Julia
Lyzhko, Ekaterina
Schlitt, Sabine
Kitzerow, Janina
Langer, Anne
Kaiser, Jochen
Naumer, Marcus J.
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Springer
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10.1007/s10548-020-00765-6
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Abstract
In Autism Spectrum Disorders (ASD), impaired response inhibition and lack of adaptation are hypothesized to underlie core ASD symptoms, such as social communication and repetitive, stereotyped behavior. Thus, the aim of the present study was to compare neural correlates of inhibition, post-error adaptation, and reaction time variability in ASD and neuro-typical control (NTC) participants by investigating possible differences in error-related changes of oscillatory MEG activity. Twelve male NTC (mean age 20.3 ± 3.7) and fourteen male patients with ASD (mean age 17.8 ± 2.9) were included in the analysis. Subjects with ASD showed increased error-related reaction time variability. MEG analysis revealed decreased beta power in the ASD group in comparison to the NTC group over the centro-parietal channels in both, the pre-stimulus and post-response interval. In the ASD group, mean centro-parietal beta power negatively correlated with dimensional autism symptoms. In both groups, false alarms were followed by an early increase in temporo-frontal theta to alpha power; and by a later decrease in alpha to beta power at central and posterior sensors. Single trial correlations were additionally studied in the ASD group, who showed a positive correlation of pre-stimulus beta power with post-response theta, alpha, and beta power, particularly after hit trials. On a broader scale, the results deliver important insights into top-down control deficits that may relate to core symptoms observed in ASD.
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Keywords
ASD , MEG , Beta-band oscillations , Motor response inhibition , Autism Spectrum Disorders (ASD)
Citation
Moliadze, V., Brodski-Guerniero, A., Schuetz, M. et al. (2020) ‘Significance of Beta-Band Oscillations in Autism Spectrum Disorders During Motor Response Inhibition Tasks: A MEG Study’, Brain Topography, doi: 10.1007/s10548-020-00765-6
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https://hdl.handle.net/10468/9838
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Applied Psychology - Journal Articles
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© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.