Enduring neurobehavioral effects induced by microbiota depletion during the adolescent period

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Date
2020-11
Authors
Lach, Gilliard
Fulling, Christine
Bastiaanssen, Thomaz F. S.
Fouhy, Fiona
O'Donovan, Aoife
Ventura-Silva, Ana Paula
Stanton, Catherine
Dinan, Timothy G.
Cryan, John F.
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Publisher
Springer
Published Version
10.1038/s41398-020-01073-0
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Abstract
The gut microbiota is an essential regulator of many aspects of host physiology. Disruption of gut microbial communities affects gut-brain communication which ultimately can manifest as changes in brain function and behaviour. Transient changes in gut microbial composition can be induced by various intrinsic and extrinsic factors, however, it is possible that enduring shifts in the microbiota composition can be achieved by perturbation at a timepoint when the gut microbiota has not fully matured or is generally unstable, such as during early life or ageing. In this study, we investigated the effects of 3-week microbiota depletion with antibiotic treatment during the adolescent period and in adulthood. Following a washout period to restore the gut microbiota, behavioural and molecular hallmarks of gut-brain communication were investigated. Our data revealed that transient microbiota depletion had long-lasting effects on microbiota composition and increased anxiety-like behaviour in mice exposed to antibiotic treatment during adolescence but not in adulthood. Similarly, gene expression in the amygdala was more severely affected in mice treated during adolescence. Taken together these data highlight the vulnerability of the gut microbiota during the critical adolescent period and the long-lasting impact manipulations of the microbiota can have on gene expression and behaviour in adulthood.
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Keywords
Gut microbiota , Intestinal microbiota , Fear extinction , Brain , Lactobacillus , Anxiety , Amygdala , Depression , Receptor , Stress
Citation
Lach, G., Fulling, C., Bastiaanssen, T. F. S., Fouhy, F., O'Donovan, A., Ventura-Silva, A. P., Stanton, C., Dinan, T. G. and Cryan, J. F. (2020) 'Enduring neurobehavioral effects induced by microbiota depletion during the adolescent period', Translational Psychiatry, 10, 382 (16pp). doi: 10.1038/s41398-020-01073-0
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https://hdl.handle.net/10468/13043
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APC Microbiome Ireland - Journal Articles
Anatomy and Neuroscience - Journal Articles
Microbiology - Journal Articles
Psychiatry - Journal Articles
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© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.