Enduring neurobehavioral effects induced by microbiota depletion during the adolescent period

Simple item page
dc.contributor.authorLach, Gilliard
dc.contributor.authorFulling, Christine
dc.contributor.authorBastiaanssen, Thomaz F. S.
dc.contributor.authorFouhy, Fiona
dc.contributor.authorO'Donovan, Aoife
dc.contributor.authorVentura-Silva, Ana Paula
dc.contributor.authorStanton, Catherine
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2022-04-06T13:36:36Z
dc.date.available2022-04-06T13:36:36Z
dc.date.issued2020-11
dc.date.updated2022-04-06T11:54:12Z
dc.description.abstractThe gut microbiota is an essential regulator of many aspects of host physiology. Disruption of gut microbial communities affects gut-brain communication which ultimately can manifest as changes in brain function and behaviour. Transient changes in gut microbial composition can be induced by various intrinsic and extrinsic factors, however, it is possible that enduring shifts in the microbiota composition can be achieved by perturbation at a timepoint when the gut microbiota has not fully matured or is generally unstable, such as during early life or ageing. In this study, we investigated the effects of 3-week microbiota depletion with antibiotic treatment during the adolescent period and in adulthood. Following a washout period to restore the gut microbiota, behavioural and molecular hallmarks of gut-brain communication were investigated. Our data revealed that transient microbiota depletion had long-lasting effects on microbiota composition and increased anxiety-like behaviour in mice exposed to antibiotic treatment during adolescence but not in adulthood. Similarly, gene expression in the amygdala was more severely affected in mice treated during adolescence. Taken together these data highlight the vulnerability of the gut microbiota during the critical adolescent period and the long-lasting impact manipulations of the microbiota can have on gene expression and behaviour in adulthood.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid382en
dc.identifier.citationLach, G., Fulling, C., Bastiaanssen, T. F. S., Fouhy, F., O'Donovan, A., Ventura-Silva, A. P., Stanton, C., Dinan, T. G. and Cryan, J. F. (2020) 'Enduring neurobehavioral effects induced by microbiota depletion during the adolescent period', Translational Psychiatry, 10, 382 (16pp). doi: 10.1038/s41398-020-01073-0en
dc.identifier.doi10.1038/s41398-020-01073-0en
dc.identifier.endpage16en
dc.identifier.issn2158-3188
dc.identifier.journaltitleTranslational Psychiatryen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13043
dc.identifier.volume10en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectGut microbiotaen
dc.subjectIntestinal microbiotaen
dc.subjectFear extinctionen
dc.subjectBrainen
dc.subjectLactobacillusen
dc.subjectAnxietyen
dc.subjectAmygdalaen
dc.subjectDepressionen
dc.subjectReceptoren
dc.subjectStressen
dc.titleEnduring neurobehavioral effects induced by microbiota depletion during the adolescent perioden
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
s41398-020-01073-0.pdf
Size:
1.86 MB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
Thumbnail Image
Name:
41398_2020_1073_MOESM1_ESM.doc
Size:
722.5 KB
Format:
Microsoft Word
Description:
Supplementary Material
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
APC Microbiome Ireland - Journal Articles
Anatomy and Neuroscience - Journal Articles
Microbiology - Journal Articles
Psychiatry - Journal Articles