Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers

dc.contributor.authorAllen, Andrew P.
dc.contributor.authorHutch, William
dc.contributor.authorBorre, Yuliya E.
dc.contributor.authorKennedy, Paul J.
dc.contributor.authorTemko, Andriy
dc.contributor.authorBoylan, Geraldine B.
dc.contributor.authorMurphy, Eileen F.
dc.contributor.authorCryan, John F.
dc.contributor.authorDinan, Timothy G.
dc.date.accessioned2016-11-14T16:19:52Z
dc.date.available2016-11-14T16:19:52Z
dc.date.issued2016-11-01
dc.description.abstractThe emerging concept of psychobiotics—live microorganisms with a potential mental health benefit—represents a novel approach for the management of stress-related conditions. The majority of studies have focused on animal models. Recent preclinical studies have identified the B. longum 1714 strain as a putative psychobiotic with an impact on stress-related behaviors, physiology and cognitive performance. Whether such preclinical effects could be translated to healthy human volunteers remains unknown. We tested whether psychobiotic consumption could affect the stress response, cognition and brain activity patterns. In a within-participants design, healthy volunteers (N=22) completed cognitive assessments, resting electroencephalography and were exposed to a socially evaluated cold pressor test at baseline, post-placebo and post-psychobiotic. Increases in cortisol output and subjective anxiety in response to the socially evaluated cold pressor test were attenuated. Furthermore, daily reported stress was reduced by psychobiotic consumption. We also observed subtle improvements in hippocampus-dependent visuospatial memory performance, as well as enhanced frontal midline electroencephalographic mobility following psychobiotic consumption. These subtle but clear benefits are in line with the predicted impact from preclinical screening platforms. Our results indicate that consumption of B. longum 1714 is associated with reduced stress and improved memory. Further studies are warranted to evaluate the benefits of this putative psychobiotic in relevant stress-related conditions and to unravel the mechanisms underlying such effects.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAllen, A. P., W. Hutch, Y. E. Borre, P. J. Kennedy, A. Temko, G. Boylan, E. Murphy, J. F. Cryan, T. G. Dinan and G. Clarke (2016). "Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers." Translational Psychiatry 6: e939. doi: 10.1038/tp.2016.191en
dc.identifier.doi10.1038/tp.2016.191
dc.identifier.endpagee939-7en
dc.identifier.issn2158-3188
dc.identifier.journaltitleTranslational Psychiatryen
dc.identifier.startpagee939-1en
dc.identifier.urihttps://hdl.handle.net/10468/3275
dc.identifier.volume6en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rights© The Authors 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectPsychobioticsen
dc.subjectStress managementen
dc.subjectB. longum 1714en
dc.subjectBifidobacterium longum 1714en
dc.subjectTranslational psychiatryen
dc.subjectTranslational psychobioticsen
dc.titleBifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteersen
dc.typeArticle (peer-reviewed)en
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