Within-host interference competition can prevent invasion of rare parasites

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dc.contributor.authorQuigley, Benjamin J. Z.
dc.contributor.authorBrown, Sam P.
dc.contributor.authorLeggett, Helen C.
dc.contributor.authorScanlan, Pauline D.
dc.contributor.authorBuckling, Angus
dc.contributor.funderNatural Environment Research Councilen
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen
dc.contributor.funderAXA Research Funden
dc.contributor.funderRoyal Societyen
dc.contributor.funderRoyal Commission for the Exhibition of 1851en
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-09-19T09:28:01Z
dc.date.available2019-09-19T09:28:01Z
dc.date.issued2017-05-15
dc.date.updated2019-09-19T09:18:32Z
dc.description.abstractCompetition between parasite species or genotypes can play an important role in the establishment of parasites in new host populations. Here, we investigate a mechanism by which a rare parasite is unable to establish itself in a host population if a common resident parasite is already present (a 'priority effect'). We develop a simple epidemiological model and show that a rare parasite genotype is unable to invade if coinfecting parasite genotypes inhibit each other's transmission more than expected from simple resource partitioning. This is because a rare parasite is more likely to be in multiply-infected hosts than the common genotype, and hence more likely to pay the cost of reduced transmission. Experiments competing interfering clones of bacteriophage infecting a bacterium support the model prediction that the clones are unable to invade each other from rare. We briefly discuss the implications of these results for host-parasite ecology and (co)evolution.en
dc.description.sponsorshipRoyal Society - Science Foundation Ireland (University Research Fellowship)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationQuigley, B. J. Z., Brown, S. P., Leggett, H. C., Scanlan, P. D. and Buckling, A. (2017) 'Within-host interference competition can prevent invasion of rare parasites', Journal of Parasitology, 145(6), pp. 770-774. doi: 10.1017/S003118201700052Xen
dc.identifier.doi10.1017/S003118201700052Xen
dc.identifier.eissn1937-2345
dc.identifier.endpage774en
dc.identifier.issn0022-3395
dc.identifier.issued6en
dc.identifier.journaltitleJournal of Parasitologyen
dc.identifier.startpage770en
dc.identifier.urihttps://hdl.handle.net/10468/8569
dc.identifier.volume145en
dc.language.isoenen
dc.publisherCambridge University Pressen
dc.rights© 2017, Cambridge University Press. All rights reserved.en
dc.subjectMultiplicity of infectionen
dc.subjectMOIen
dc.subjectInterference competitionen
dc.subjectPositive frequency dependenceen
dc.subjectBacteriaen
dc.subjectPhageen
dc.titleWithin-host interference competition can prevent invasion of rare parasitesen
dc.typeArticle (peer-reviewed)en
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