Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year

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dc.contributor.authorKennedy, Elizabeth A.
dc.contributor.authorConnolly, Jennifer
dc.contributor.authorHourihane, Jonathan O'B.
dc.contributor.authorFallon, Padraic G.
dc.contributor.authorMcLean, W. H. Irwin
dc.contributor.authorMurray, Deirdre M.
dc.contributor.authorJo, Jay-Hyun
dc.contributor.authorSegre, Julia A.
dc.contributor.authorKong, Heidi H.
dc.contributor.authorIrvine, Alan D.
dc.contributor.funderWellcome Trusten
dc.contributor.funderNational Human Genome Research Instituteen
dc.contributor.funderNational Institutes of Healthen
dc.contributor.funderNational Cancer Instituteen
dc.contributor.funderFood Standards Agencyen
dc.contributor.funderNational Children’s Research Centre, Irelanden
dc.contributor.funderMinistry of Health and Welfare, South Koreaen
dc.date.accessioned2017-01-06T16:19:39Z
dc.date.available2017-01-06T16:19:39Z
dc.date.issued2016-09-05
dc.date.updated2017-01-06T16:01:32Z
dc.description.abstractBackground: Disease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus dominance. The temporal transition of the skin microbiome between early infancy and the dysbiosis of established AD is unknown. Methods: We randomly selected 50 children from the Cork Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE) longitudinal birth cohort for microbiome sampling at 3 points in the first 6 months of life at 4 skin sites relevant to AD: the antecubital and popliteal fossae, nasal tip, and cheek. We identified 10 infants with AD and compared them with 10 randomly selected control infants with no AD. We performed bacterial 16S ribosomal RNA sequencing and analysis directly from clinical samples. Results: Bacterial community structures and diversity shifted over time, suggesting that age strongly affects the skin microbiome in infants. Unlike established AD, these patients with infantile AD did not have noticeably dysbiotic communities before or with disease and were not colonized by S aureus. In comparing patients and control subjects, infants who had affected skin at month 12 had statistically significant differences in bacterial communities on the antecubital fossa at month 2 compared with infants who were unaffected at month 12. In particular, commensal staphylococci were significantly less abundant in infants affected at month 12, suggesting that this genus might protect against the later development of AD. Conclusions: This study suggests that 12-month-old infants with AD were not colonized with S aureus before having AD. Additional studies are needed to confirm whether colonization with commensal staphylococci modulates skin immunity and attenuates development of AD.en
dc.description.sponsorshipMinistry of Health and Welfare, South Korea (Korean Health Technology R&D Project, HI15C1095))en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKennedy, E. A., Connolly, J., Hourihane, J. O. B., Fallon, P. G., McLean, W. H. I., Murray, D., Jo, J.-H., Segre, J. A., Kong, H. H. and Irvine, A. D. (2017) 'Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year', Journal of Allergy and Clinical Immunology, 139(1), pp. 166-172. doi:10.1016/j.jaci.2016.07.029en
dc.identifier.doi10.1016/j.jaci.2016.07.029
dc.identifier.endpage172en
dc.identifier.issn0091-6749
dc.identifier.issued1en
dc.identifier.journaltitleJournal of Allergy and Clinical Immunologyen
dc.identifier.startpage166en
dc.identifier.urihttps://hdl.handle.net/10468/3445
dc.identifier.volume139en
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2016 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectStaphylococcus aureusen
dc.subjectAtopic dermatitisen
dc.subjectSkinen
dc.subjectMicrobiomeen
dc.subjectLongitudinal birth cohorten
dc.subject16S sequencingen
dc.titleSkin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 yearen
dc.typeArticle (peer-reviewed)en
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