Application of percolation threshold to disintegration and dissolution of ibuprofen tablets with different microcrystalline cellulose grades

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dc.contributor.authorQueiroz, Ana Luiza P.
dc.contributor.authorWood, Barbara
dc.contributor.authorFaisal, Waleed
dc.contributor.authorFarag, Fatma
dc.contributor.authorGarvie-Cook, Hazel
dc.contributor.authorGlennon, Brian
dc.contributor.authorVucen, Sonja
dc.contributor.authorCrean, Abina M.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Regional Development Funden
dc.date.accessioned2021-02-11T13:00:53Z
dc.date.available2021-02-11T13:00:53Z
dc.date.issued2020-09-03
dc.date.updated2021-02-09T11:51:49Z
dc.description.abstractThe study presented was conducted to determine whether a percolation threshold value, previously determined for ibuprofen/microcrystalline cellulose (MCC) blends using percolation theory and compression data (Queiroz et al., 2019), could translate to tablet disintegration and dissolution data. The influence of MCC grade (air stream dried versus spray dried) on tablet disintegration and dissolution was also investigated. Complementary to conventional disintegration and dissolution testing, Raman imaging determined drug distribution within tablets, and in-line particle video microscopy (PVM) and focused-beam reflectance measurement (FBRM) monitored tablet disintegration. Tablets were prepared containing 0–30% w/w ibuprofen. Raman imaging confirmed the percolation threshold by quantifying the number and equivalent circular diameters of ibuprofen domains on tablet surfaces. Across the percolation threshold, a step change in dissolution behaviour occurred, and tablets containing air stream dried MCC showed slower disintegration rates compared to tablets containing spray dried MCC. Dissolution measurements confirmed experimentally a percolation threshold in agreement with that determined using percolation theory and compression data. An increase in drug domains, due to cluster formation, and less efficient tablet disintegration contributed to slower ibuprofen dissolution above the percolation threshold. Slower dissolution was measured for tablets containing air stream dried compared to spray dried MCC.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid119838en
dc.identifier.citationQueiroz, A. L. P., Wood, B., Faisal, W., Farag, F., Garvie-Cook, H., Glennon, B., Vucen, S. and Crean, A. M. (2020) 'Application of percolation threshold to disintegration and dissolution of ibuprofen tablets with different microcrystalline cellulose grades', International Journal of Pharmaceutics, 589, 119838 (14 pp). doi: 10.1016/j.ijpharm.2020.119838en
dc.identifier.doi10.1016/j.ijpharm.2020.119838en
dc.identifier.endpage14en
dc.identifier.issn0378-5173
dc.identifier.journaltitleInternational Journal of Pharmaceuticsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/11061
dc.identifier.volume589en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/en
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0378517320308231
dc.rights© 2020 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectDisintegrationen
dc.subjectDissolutionen
dc.subjectFocused-beam reflectance measurement (FBRM)en
dc.subjectMicrocrystalline celluloseen
dc.subjectRaman imagingen
dc.subjectTabletsen
dc.titleApplication of percolation threshold to disintegration and dissolution of ibuprofen tablets with different microcrystalline cellulose gradesen
dc.typeArticle (peer-reviewed)en
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