Microbiome-immune interactions and relationship to asthma severity

Trujillo, Juan; Lunjani, Nonhlanhla; Ryan, Dermot; O’Mahony, Liam

Microbiome-immune interactions and relationship to asthma severity

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Microbiome_immune_interactions_and_relationship_to_asthma_severity (1).pdf(172.49 KB)

Accepted Version

Date

2021-12-22

Authors

Trujillo, Juan

Lunjani, Nonhlanhla

Ryan, Dermot

O’Mahony, Liam

Publisher

Elsevier Inc.

Published Version

10.1016/j.jaci.2021.12.774

Abstract

Microbial-derived factors are integral components of the molecular circuitry that regulates immune and metabolic functions required for host fitness and survival. Recent advances in culture-based methods and sequencing technologies have revealed previously unappreciated complex communities of bacteria, fungi, and viruses that inhabit the respiratory tract and whose composition and activity are correlated with acute and chronic inflammatory responses. In this article, we will summarize our knowledge to date on the role of the microbiota in severe asthma, acknowledging that data specific to severe asthma are currently limited.

Keywords

Microbiome , Microbiota , Severe asthma , Inflammation

Citation

Trujillo, J., Lunjani, N., Ryan, D. and O’Mahony, L. (2021) 'Microbiome-immune interactions and relationship to asthma severity', Journal of Allergy and Clinical Immunology, 149(2), pp. 533 - 534. doi: 10.1016/j.jaci.2021.12.774