Estimation of the maternal vitamin D intake that maintains circulating 25-hydroxyvitamin D in late gestation at a concentration sufficient to keep umbilical cord sera >= 25-30 nmol/L: a dose-response, double-blind, randomized placebo-controlled trial in pregnant women at northern latitude

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dc.contributor.authorO'Callaghan, Karen M.
dc.contributor.authorHennessy, Áine
dc.contributor.authorHull, George L. J.
dc.contributor.authorHealy, Karina
dc.contributor.authorRitz, Christian
dc.contributor.authorKenny, Louise C.
dc.contributor.authorCashman, Kevin D.
dc.contributor.authorKiely, Mairead E.
dc.contributor.funderEuropean Commission
dc.date.accessioned2018-08-29T15:47:29Z
dc.date.available2018-08-29T15:47:29Z
dc.date.issued2018
dc.description.abstractBackground: In the absence of dose-response data, Dietary Reference Values for vitamin D in nonpregnant adults are extended to pregnancy. Objective: The aim was to estimate vitamin D intake needed to maintain maternal 25-hydroxyvitamin D [25(OH)D] in late gestation at a concentration sufficient to prevent newborn 25(OH)D <25-30 nmol/L, a threshold indicative of increased risk of nutritional rickets. Design: We conducted a 3-arm, dose-response, double-blind, randomized placebo-controlled trial in Cork, Ireland (51.9 degrees N). A total of 144 white-skinned pregnant women were assigned to receive 0, 10 (400 IU), or 20 (800 IU) mu g vitamin D-3/d from <= 18 wk of gestation. Vitamin D metabolites at 14, 24, and 36 wk of gestation and in cord sera, including 25(OH)D-3, 3-epi-25(OH)D-3, 24,25(OH)(2)D-3, and 25(OH)D-2 were quantified by liquid chromatography-tandem mass spectrometry. A curvilinear regression model predicted the total vitamin D intake (from diet and antenatal supplements plus treatment dose) that maintained maternal 25(OH)D in late gestation at a concentration sufficient to maintain cord 25(OH)D at >= 25-30 nmol/L. Results: Mean +/- SD baseline 25(OH)D was 54.9 +/- 10.7 nmol/L. Total vitamin D intakes at the study endpoint (36 wk of gestation) were 12.1 +/- 8.0, 21.9 +/- 5.3, and 33.7 +/- 5.1 mu g/d in the placebo and 10-mu g and 20-mu g vitamin D-3 groups, respectively; and 25(OH)D was 24.3 +/- 5.8 and 29.2 +/- 5.6 nmol/L higher in the 10- and 20-mu g groups, respectively, compared with placebo (P < 0.001). For maternal 25(OH)D concentrations >= 50 nmol/L, 95% of cord sera were >= 30 nmol/L and 99% were > 25 nmol/L. The estimated vitamin D intake required to maintain serum 25(OH)D at >= 50 nmol/L in 97.5% of women was 28.9 mu g/d. Conclusions: Thirty micrograms of vitamin D per day safely maintained serum 25(OH)D concentrations at >= 50 nmol/L in almost all white-skinned women during pregnancy at a northern latitude, which kept 25(OH)D at > 25 nmol/L in 99% and >= 30 nmol/L in 95% of umbilical cord sera.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Callaghan, K. M., Hennessy, Á., Hull, G. L. J., Healy, K., Ritz, C., Kenny, L. C., Cashman, K. D. and Kiely, M. E. (2018) 'Estimation of the maternal vitamin D intake that maintains circulating 25-hydroxyvitamin D in late gestation at a concentration sufficient to keep umbilical cord sera ≥25–30 nmol/L: a dose-response, double-blind, randomized placebo-controlled trial in pregnant women at northern latitude', The American Journal of Clinical Nutrition, 108(1), pp. 77-91. doi: 10.1093/ajcn/nqy064en
dc.identifier.doi10.1093/ajcn/nqy064
dc.identifier.endpage91
dc.identifier.issn0002-9165
dc.identifier.issued1
dc.identifier.journaltitleAmerican Journal of Clinical Nutritionen
dc.identifier.startpage77
dc.identifier.urihttps://hdl.handle.net/10468/6683
dc.identifier.volume108
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODIN
dc.relation.urihttps://academic.oup.com/ajcn/article/108/1/77/5033927
dc.rights© 2018, American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits noncommercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject25-hydroxyvitamin Den
dc.subjectdietary requirementsen
dc.subjectdose-responseen
dc.subjectODINen
dc.subjectNeonatalen
dc.subjectPregnancyen
dc.subjectRandomized controlled trialen
dc.subjectVitamin Den
dc.subjectVitamin D requirementsen
dc.titleEstimation of the maternal vitamin D intake that maintains circulating 25-hydroxyvitamin D in late gestation at a concentration sufficient to keep umbilical cord sera >= 25-30 nmol/L: a dose-response, double-blind, randomized placebo-controlled trial in pregnant women at northern latitudeen
dc.typeArticle (peer-reviewed)en
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