Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)

dc.contributor.authorPazukhina, Ekaterina
dc.contributor.authorAndreeva, Margarita
dc.contributor.authorSpiridonova, Ekaterina
dc.contributor.authorBobkova, Polina
dc.contributor.authorShikhaleva, Anastasia
dc.contributor.authorEl-Taravi, Yasmin
dc.contributor.authorRumyantsev, Mikhail
dc.contributor.authorGamirova, Aysylu
dc.contributor.authorBairashevskaia, Anastasiia
dc.contributor.authorPetrova, Polina
dc.contributor.authorBaimukhambetova, Dina
dc.contributor.authorPikuza, Maria
dc.contributor.authorAbdeeva, Elina
dc.contributor.authorFilippova, Yulia
dc.contributor.authorDeunezhewa, Salima
dc.contributor.authorNekliudov, Nikita
dc.contributor.authorBugaeva, Polina
dc.contributor.authorBulanov, Nikolay
dc.contributor.authorAvdeev, Sergey
dc.contributor.authorKapustina, Valentina
dc.contributor.authorGuekht, Alla
dc.contributor.authorDunnGalvin, Audrey
dc.contributor.authorComberiati, Pasquale
dc.contributor.authorPeroni, Diego G.
dc.contributor.authorApfelbacher, Christian
dc.contributor.authorGenuneit, Jon
dc.contributor.authorReyes, Luis Felipe
dc.contributor.authorBrackel, Caroline L. H.
dc.contributor.authorFomin, Victor
dc.contributor.authorSvistunov, Andrey A.
dc.contributor.authorTimashev, Peter
dc.contributor.authorMazankova, Lyudmila
dc.contributor.authorMiroshina, Alexandra
dc.contributor.authorSamitova, Elmira
dc.contributor.authorBorzakova, Svetlana
dc.contributor.authorBondarenko, Elena
dc.contributor.authorKorsunskiy, Anatoliy A.
dc.contributor.authorCarson, Gail
dc.contributor.authorSigfrid, Louise
dc.contributor.authorScott, Janet T.
dc.contributor.authorGreenhawt, Matthew
dc.contributor.authorBuonsenso, Danilo
dc.contributor.authorSemple, Malcolm G.
dc.contributor.authorWarner, John O.
dc.contributor.authorOlliaro, Piero
dc.contributor.authorNeedham, Dale M.
dc.contributor.authorGlybochko, Petr
dc.contributor.authorButnaru, Denis
dc.contributor.authorOsmanov, Ismail M.
dc.contributor.authorMunblit, Daniel
dc.contributor.authorSechenov StopCOVID Research Team
dc.description.abstractBackground: Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalised adults and children and assessed risk factors. Methods: Prospective cohort study of children and adults with confirmed COVID-19 in Moscow, hospitalised between April and August, 2020. Two follow-up telephone interviews, using the International Severe Acute Respiratory and Emerging Infection Consortium survey, were performed at 6 and 12 months after discharge. Results: One thousand thirteen of 2509 (40%) of adults and 360 of 849 (42%) of children discharged participated in both the 6- and 12-month follow-ups. PCC prevalence was 50% (95% CI 47–53) in adults and 20% (95% CI 16–24) in children at 6 months, with decline to 34% (95% CI 31–37) and 11% (95% CI 8–14), respectively, at 12 months. In adults, female sex was associated with PCC at 6- and 12-month follow-up (OR 2.04, 95% CI 1.57 to 2.65) and (OR 2.04, 1.54 to 2.69), respectively. Pre-existing hypertension (OR 1.42, 1.04 to 1.94) was associated with post-COVID-19 condition at 12 months. In children, neurological comorbidities were associated with PCC both at 6 months (OR 4.38, 1.36 to 15.67) and 12 months (OR 8.96, 2.55 to 34.82) while allergic respiratory diseases were associated at 12 months (OR 2.66, 1.04 to 6.47). Conclusions: Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. In adults, females and persons with pre-existing hypertension, and in children, persons with neurological comorbidities or allergic respiratory diseases are at higher risk of PCC.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.identifier.citationPazukhina, E., Andreeva, M., Spiridonova, E., Bobkova, P., Shikhaleva, A., El-Taravi, Y., Rumyantsev, M., Gamirova, A., Bairashevskaia, A., Petrova, P., Baimukhambetova, D., Pikuza, M., Abdeeva, E., Filippova, Y., Deunezhewa, S.,Nekliudov, N., Bugaeva, P., Bulanov, N., Avdeev, S., Kapustina, V., Guekht, A., DunnGalvin, A., Comberiati, P., Peroni, D. G., Apfelbacher, C., Genuneit, J., Reyes, L. F., Brackel, C. L. H., Fomin, V., Svistunov, A. A., Timashev, P., Mazankova, L., Miroshina, A., Samitova, E., Borzakova, S., Bondarenko, E., Korsunskiy, A. A., Carson, G., Sigfrid, L., Scott, J. T., Greenhawt, M., Buonsenso, D., Semple, M. G., Warner, J. O., Olliaro, P., Needham, D. M., Glybochko, P., Butnaru, D., Osmanov, I. M., Munblit, D. and the Sechenov StopCOVID Research Team (2022) 'Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)', BMC Medicine, 20(1), 244 (12pp). doi: 10.1186/s12916-022-02448-4en
dc.identifier.journaltitleBMC Medicineen
dc.publisherBioMed Central Ltden
dc.rights© 2022, the Authors. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.en
dc.subjectCOVID-19 sequelaeen
dc.subjectLong COVIDen
dc.subjectPost-acute sequelae of SARS-CoV-2en
dc.subjectPost-COVID-19 conditionen
dc.subjectRisk factoren
dc.titlePrevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)en
dc.typeArticle (peer-reviewed)en
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