Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)

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Pazukhina, Ekaterina
Andreeva, Margarita
Spiridonova, Ekaterina
Bobkova, Polina
Shikhaleva, Anastasia
El-Taravi, Yasmin
Rumyantsev, Mikhail
Gamirova, Aysylu
Bairashevskaia, Anastasiia
Petrova, Polina
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Background: Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalised adults and children and assessed risk factors. Methods: Prospective cohort study of children and adults with confirmed COVID-19 in Moscow, hospitalised between April and August, 2020. Two follow-up telephone interviews, using the International Severe Acute Respiratory and Emerging Infection Consortium survey, were performed at 6 and 12 months after discharge. Results: One thousand thirteen of 2509 (40%) of adults and 360 of 849 (42%) of children discharged participated in both the 6- and 12-month follow-ups. PCC prevalence was 50% (95% CI 47–53) in adults and 20% (95% CI 16–24) in children at 6 months, with decline to 34% (95% CI 31–37) and 11% (95% CI 8–14), respectively, at 12 months. In adults, female sex was associated with PCC at 6- and 12-month follow-up (OR 2.04, 95% CI 1.57 to 2.65) and (OR 2.04, 1.54 to 2.69), respectively. Pre-existing hypertension (OR 1.42, 1.04 to 1.94) was associated with post-COVID-19 condition at 12 months. In children, neurological comorbidities were associated with PCC both at 6 months (OR 4.38, 1.36 to 15.67) and 12 months (OR 8.96, 2.55 to 34.82) while allergic respiratory diseases were associated at 12 months (OR 2.66, 1.04 to 6.47). Conclusions: Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. In adults, females and persons with pre-existing hypertension, and in children, persons with neurological comorbidities or allergic respiratory diseases are at higher risk of PCC.
Adults , Children , COVID-19 , COVID-19 sequelae , Long COVID , Post-acute sequelae of SARS-CoV-2 , infection , PASC , Post-COVID-19 condition , Prevalence , Risk factor
Pazukhina, E., Andreeva, M., Spiridonova, E., Bobkova, P., Shikhaleva, A., El-Taravi, Y., Rumyantsev, M., Gamirova, A., Bairashevskaia, A., Petrova, P., Baimukhambetova, D., Pikuza, M., Abdeeva, E., Filippova, Y., Deunezhewa, S.,Nekliudov, N., Bugaeva, P., Bulanov, N., Avdeev, S., Kapustina, V., Guekht, A., DunnGalvin, A., Comberiati, P., Peroni, D. G., Apfelbacher, C., Genuneit, J., Reyes, L. F., Brackel, C. L. H., Fomin, V., Svistunov, A. A., Timashev, P., Mazankova, L., Miroshina, A., Samitova, E., Borzakova, S., Bondarenko, E., Korsunskiy, A. A., Carson, G., Sigfrid, L., Scott, J. T., Greenhawt, M., Buonsenso, D., Semple, M. G., Warner, J. O., Olliaro, P., Needham, D. M., Glybochko, P., Butnaru, D., Osmanov, I. M., Munblit, D. and the Sechenov StopCOVID Research Team (2022) 'Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)', BMC Medicine, 20(1), 244 (12pp). doi: 10.1186/s12916-022-02448-4