Diet and depression: exploring the biological mechanisms of action

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dc.contributor.authorMarx, Wolfgang
dc.contributor.authorLane, Melissa
dc.contributor.authorHockey, Meghan
dc.contributor.authorAslam, Hajara
dc.contributor.authorBerk, Michael
dc.contributor.authorWalder, Ken
dc.contributor.authorBorsini, Alessandra
dc.contributor.authorFirth, Joseph
dc.contributor.authorPariante, Carmine M.
dc.contributor.authorBerding, Kirsten
dc.contributor.authorCryan, John F.
dc.contributor.authorClarke, Gerard
dc.contributor.authorCraig, Jeffrey M.
dc.contributor.authorSu, Kuan-Pin
dc.contributor.authorMischoulon, David
dc.contributor.authorGomez-Pinilla, Fernando
dc.contributor.authorFoster, Jane A
dc.contributor.authorCani, Patrice D.
dc.contributor.authorThuret, Sandrine
dc.contributor.authorStaudacher, Heidi M.
dc.contributor.authorSánchez-Villegas, Almudena
dc.contributor.authorArshad, Husnain
dc.contributor.authorAkbaraly, Tasnime
dc.contributor.authorO'Neil, Adrienne
dc.contributor.authorSegasby, Toby
dc.contributor.authorJacka, Felice N.
dc.contributor.funderDeakin Universityen
dc.contributor.funderMultiple Sclerosis Research Australiaen
dc.contributor.funderAustralian Rotary Healthen
dc.contributor.funderNational Health and Medical Research Councilen
dc.contributor.funderMedical Research Councilen
dc.contributor.funderHorizon 2020en
dc.contributor.funderNational Institute for Health Researchen
dc.contributor.funderIrish Research Councilen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschungen
dc.contributor.funderHealth Research Boarden
dc.contributor.funderInstitute for Scientific Information on Coffee, UKen
dc.contributor.funderSaks Kavanaugh Foundation, United Statesen
dc.contributor.funderUniversity of Manchesteren
dc.contributor.funderUK Research and Innovationen
dc.contributor.funderAustralian Research Councilen
dc.contributor.funderWaterloo Foundationen
dc.contributor.funderDNA Genoteken
dc.contributor.funderTrajan Scientific and Medical, Australiaen
dc.contributor.funderMinistry of Science and Technology, Taiwanen
dc.contributor.funderNational Health Research Institutesen
dc.contributor.funderUniversidade de Macauen
dc.contributor.funderMinistry of Educationen
dc.contributor.funderChina Medical University, Taiwanen
dc.contributor.funderChina Medical University Hospitalen
dc.contributor.funderNordic Naturals, United Statesen
dc.contributor.funderNational Institute of Neurological Disorders and Strokeen
dc.contributor.funderNatural Sciences and Engineering Research Council of Canadaen
dc.contributor.funderOntario Brain Instituteen
dc.contributor.funderFonds Baillet Latouren
dc.contributor.funderFonds De La Recherche Scientifique - FNRSen
dc.contributor.funderEuropean Research Councilen
dc.contributor.funderCentre Hospitalier Régional Universitaire de Montpellieren
dc.contributor.funderNational Heart Foundation of Australiaen
dc.contributor.funderWilson Foundationen
dc.date.accessioned2020-12-08T17:08:37Z
dc.date.available2020-12-08T17:08:37Z
dc.date.issued2020-11-03
dc.date.updated2020-12-07T10:47:59Z
dc.description.abstractThe field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression onset and symptom management. To guide future clinical trials and targeted dietary therapies, this review provides an overview of what is currently known regarding underlying mechanisms of action by which diet may influence mental and brain health. The mechanisms of action associating diet with health outcomes are complex, multifaceted, interacting, and not restricted to any one biological pathway. Numerous pathways were identified through which diet could plausibly affect mental health. These include modulation of pathways involved in inflammation, oxidative stress, epigenetics, mitochondrial dysfunction, the gut microbiota, tryptophan-kynurenine metabolism, the HPA axis, neurogenesis and BDNF, epigenetics, and obesity. However, the nascent nature of the nutritional psychiatry field to date means that the existing literature identified in this review is largely comprised of preclinical animal studies. To fully identify and elucidate complex mechanisms of action, intervention studies that assess markers related to these pathways within clinically diagnosed human populations are needed.en
dc.description.sponsorshipDeakin University (Alfred Deakin Postdoctoral Research Fellowship; PhD Scholarship; Postgraduate Industry Research Scholarship); Multiple Sclerosis Research Australia (Early-Career Fellowship); Australian Rotary Health (PhD Scholarship); NHMRC (Senior Principal Research Fellowship 1059660 and 1156072); UK Medical Research Council (Grants MR/L014815/1; MR/J002739/1; MR/N029488/1); Irish Research Council (Post-doctoral fellowship); Swiss National Foundation (Sinergia grant GUT-BRAIN); Irish Research Council (Postgraduate Scholarship GOIPG/2019/3198; GOIPG/2018/2560); Health Research Board (Grant number ILP-POR-2017-013); University of Manchester (Presidential Fellowship P123958); UK Research and Innovation (Future Leaders Fellowship MR/T021780/1); Australian Research Council (DP190103081); National Health and Medical Research Council (APP114333; APP1079102); Ministry of Science and Technology, Taiwan (MOST 106-2314-B-039-027-MY3; 108-2320-B-039-048; 108-2813-C-039-133-B; 108-2314-B-039-016); National Health Research Institutes, Taiwan (NHRI-EX108-10528NI Universidade de Macau, China (MYRG2018-00242-ICMS); Ministry of Education, Taiwan (CMRC-CMA-3); China Medical University, Taiwan (CMU108-SR-106), China Medical University Hospital, Taiwan (CRS-108-048, DMR-108-216 and DMR-109-102); Fonds Baillet Latour (Grant for Medical Research 2015); Fonds de la Recherche Scientifique (FNRS, FRFS-WELBIO: WELBIO-CR-2019C-02R); ERC (Starting Grant 2013 (336452-ENIGMO); Heart Foundation Australia and Wilson Foundation (Future Leader Fellowship (#101160); Horizon 2020 (Grant SC1-BHC-01-2019); Science Foundation Ireland (SFI/12/RC/2273-P2), (15/JPHDHL/3270); 16/ERAHDHL/3362)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMarx, W., Lane, M., Hockey, M., Aslam, H., Berk, M., Walder, K., Borsini, A., Firth, J., Pariante, C. M., Berding, K., Cryan, J. F., Clarke, G., Craig, J. M., Su, K.-P., Mischoulon, D., Gomez-Pinilla, F., Foster, J. A., Cani, P. D., Thuret, S., Staudacher, H. M., Sánchez-Villegas, A., Arshad, H., Akbaraly, T., O’Neil, A., Segasby, T. and Jacka, F. N. (2020) ‘Diet and depression: exploring the biological mechanisms of action’, Molecular Psychiatry. doi: 10.1038/s41380-020-00925-xen
dc.identifier.doi10.1038/s41380-020-00925-xen
dc.identifier.eissn1476-5578
dc.identifier.issn1359-4184
dc.identifier.journaltitleMolecular Psychiatryen
dc.identifier.urihttps://hdl.handle.net/10468/10821
dc.language.isoenen
dc.publisherSpringer Nature Limiteden
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/848228/EU/Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe/DISCOvERIEen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/797592/EU/Gut microbiota-Microglia Interactions in NeuroDevelopment/GutMINDen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEXen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP2::ERC/336452/EU/Gut microbiota, innate immunity and endocannabinoid system interactions link metabolic inflammation with the hallmarks of obesity and type 2 diabetes/ENIGMOen
dc.rights© 2020, the Authors, under exclusive licence to Springer Nature Limited. This is a post-peer-review, pre-copyedit version of an article published in Molecular Psychiatry on 3 November 2020. The final authenticated version is available online at: https://doi.org/10.1038/s41380-020-00925-xen
dc.subjectDieten
dc.subjectMental healthen
dc.subjectNutritional psychiatryen
dc.titleDiet and depression: exploring the biological mechanisms of actionen
dc.typeArticle (peer-reviewed)en
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