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Pregnancy‐specific glycoprotein 1 promotes wound closure in animal models
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Date
2025-04-29
Authors
Moore, Tom
Williams, John M.
Barriscale Walsh, Kathy
Whelan, Derek
Clover, James
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley & Sons, Inc.
Published Version
Abstract
Recombinant human PSG1 administered intradermally at wound margins enhances skin wound healing in the mouse and pig, including in an acute diabetic mouse model. A highly significant effect on wound re-epithelialisation was observed in the pig, and PSG1 treatment of the human HaCaT keratinocyte cell line regulated wound healing-associated genes and enhanced scratch wound closure in cell monolayers in vitro. Clinical use of PSG1 might enhance closure of incisional and traumatic wounds and enhance re-epithelialisation of burn injuries.
Description
Keywords
Sepithelialisation , Keratinocyte , Pregnancy-specific glycoprotein , TGFβ1 , Wound therapy
Citation
Moore, T., Williams, J. M., Barriscale Walsh, K., Whelan, D. and Clover, J. (2025) 'Pregnancy-specific glycoprotein 1 promotes wound closure in animal models', European Journal of Clinical Investigation, e70056 (7pp). https://doi.org/10.1111/eci.70056
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Copyright
© 2025, Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd. This is the accepted version of the following item: Moore, T., Williams, J. M., Barriscale Walsh, K., Whelan, D. and Clover, J. (2025) 'Pregnancy-specific glycoprotein 1 promotes wound closure in animal models', European Journal of Clinical Investigation, e70056 (7pp), which has been published in final form at: https://doi.org/10.1111/eci.70056 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.