Pregnancy‐specific glycoprotein 1 promotes wound closure in animal models

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dc.check.date2026-04-29en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorMoore, Tomen
dc.contributor.authorWilliams, John M.en
dc.contributor.authorBarriscale Walsh, Kathyen
dc.contributor.authorWhelan, Dereken
dc.contributor.authorClover, Jamesen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEnterprise Irelanden
dc.date.accessioned2025-05-22T10:46:53Z
dc.date.available2025-05-22T10:46:53Z
dc.date.issued2025-04-29en
dc.description.abstractRecombinant human PSG1 administered intradermally at wound margins enhances skin wound healing in the mouse and pig, including in an acute diabetic mouse model. A highly significant effect on wound re-epithelialisation was observed in the pig, and PSG1 treatment of the human HaCaT keratinocyte cell line regulated wound healing-associated genes and enhanced scratch wound closure in cell monolayers in vitro. Clinical use of PSG1 might enhance closure of incisional and traumatic wounds and enhance re-epithelialisation of burn injuries.en
dc.description.sponsorshipScience Foundation Ireland and Enterprise Ireland (Technology Innovation Development Award)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide70056en
dc.identifier.citationMoore, T., Williams, J. M., Barriscale Walsh, K., Whelan, D. and Clover, J. (2025) 'Pregnancy-specific glycoprotein 1 promotes wound closure in animal models', European Journal of Clinical Investigation, 55(8), e70056 (7pp). https://doi.org/10.1111/eci.70056en
dc.identifier.doi10.1111/eci.70056en
dc.identifier.endpage7en
dc.identifier.issn0014-2972en
dc.identifier.issn1365-2362en
dc.identifier.issued8en
dc.identifier.journaltitleEuropean Journal of Clinical Investigationen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/17559
dc.identifier.volume55en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.relation.ispartofEuropean Journal of Clinical Investigationen
dc.rights© 2025, Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd. This is the accepted version of the following item: Moore, T., Williams, J. M., Barriscale Walsh, K., Whelan, D. and Clover, J. (2025) 'Pregnancy-specific glycoprotein 1 promotes wound closure in animal models', European Journal of Clinical Investigation, e70056 (7pp), which has been published in final form at: https://doi.org/10.1111/eci.70056 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectSepithelialisationen
dc.subjectKeratinocyteen
dc.subjectPregnancy-specific glycoproteinen
dc.subjectTGFβ1en
dc.subjectWound therapyen
dc.titlePregnancy‐specific glycoprotein 1 promotes wound closure in animal modelsen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
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