Fibromyalgia syndrome – a risk factor for poor outcomes following orthopaedic surgery: A systematic review

Thumbnail Image
Fibromyalgia syndrome.pdf(380.54 KB)
Accepted version
Figure1_FU.doc(37.5 KB)
Additional file 1
Figure 2_rev1.pdf(9.08 KB)
Additional file 2
Table 1.docx(21.45 KB)
Additional file 3
Table 2.docx(19.04 KB)
Additional file 4
D'Onghia, Martina
Ciaffi, Jacopo
McVeigh, Joseph G.
Di Martino, Alberto
Faldini, Cesare
Ablin, Jacob N.
Meliconi, Riccardo
Ursini, Francesco
Journal Title
Journal ISSN
Volume Title
Research Projects
Organizational Units
Journal Issue
Background: Fibromyalgia (FM) is a complex syndrome incorporating many features associated with poor outcome in orthopaedic surgery. Aim of the present review was to comprehensively characterize the available evidence on the consequences of pre-existent FM on the outcomes of orthopaedic surgery. Methods: We performed a systematic search in MedLine and Web of Science (WOS) to identify studies evaluating the effect of FM on patient-centred outcomes, opioids consumption and postoperative complications. Results: The search strategy identified 519 records in PubMed and 507 in WOS. A total of 27 articles were deemed eligible for inclusion in qualitative synthesis. Based on quality assessment, 10 studies were rated as good quality, 10 as fair quality and 7 as poor quality. Studies reporting the prevalence of FM in consecutive patients undergoing orthopaedic surgery (n = 19) were included in quantitative synthesis. The pooled prevalence of FM in patients undergoing orthopaedic surgery was 4.1% (95% CI: 2.4–6.8) in those receiving hip or knee surgery, 10.1% (95% CI: 5.7–17.2) in those receiving shoulder or elbow surgery and 21.0% (95% CI: 18.5–23.7) in those receiving spinal surgery. The results of our systematic review consistently report FM as a significant risk factor for less satisfaction, higher pain, worse functional outcome, increased risk for postoperative opioids prescription and higher rate of medical and surgical complications following orthopaedic surgery. Conclusion: Identifying pre-existing FM in patients scheduled for elective orthopaedic surgery may help to better assess the benefit/risk ratio, improve patients’ awareness and minimize any discrepancy between expectancy and results.
Fibromyalgia , Widespread pain , Orthopaedic surgery , Knee arthroplasty , Hip arthroplasty , Spinal surgery
D’Onghia, M., Ciaffi, J., McVeigh, J.G., Di Martino, A., Faldini, C., Ablin, J.N., Meliconi, R. and Ursini, F. (2021) ‘Fibromyalgia syndrome – a risk factor for poor outcomes following orthopaedic surgery: A systematic review’, Seminars in Arthritis and Rheumatism, 51(4), pp. 793–803. Available at:
Link to publisher’s version