A systematic review and meta-regression analysis of the vitamin D intake-serum 25-hydroxyvitamin D relationship to inform European recommendations
| dc.contributor.author | Cashman, Kevin D. | |
| dc.contributor.author | Fitzgerald, Anthony P. | |
| dc.contributor.author | Kiely, Mairead E. | |
| dc.contributor.author | Seamans, Kelly M. | |
| dc.contributor.funder | Sixth Framework Programme | en |
| dc.date.accessioned | 2012-12-20T15:40:54Z | |
| dc.date.available | 2012-12-20T15:40:54Z | |
| dc.date.copyright | 2011 | |
| dc.date.issued | 2011-12 | |
| dc.date.updated | 2012-12-19T16:01:19Z | |
| dc.description.abstract | The present study used a systematic review approach to identify relevant randomised control trials (RCT) with vitamin D and then apply meta-regression to explore the most appropriate model of the vitamin D intake–serum 25-hydroxyvitamin D (25(OH)D) relationship to underpin setting reference intake values. Methods included an updated structured search on Ovid MEDLINE; rigorous inclusion/exclusion criteria; data extraction; and meta-regression (using different model constructs). In particular, priority was given to data from winter-based RCT performed at latitudes >49•58°N (n 12). A combined weighted linear model meta-regression analyses of natural log (Ln) total vitamin D intake (i.e. diet and supplemental vitamin D) versus achieved serum 25(OH)D in winter (that used by the North American Dietary Reference Intake Committee) produced a curvilinear relationship (mean (95% lower CI) serum 25(OH)D (nmol/l) = 9•2 (8•5) Ln (total vitamin D)). Use of non-transformed total vitamin D intake data (maximum 1400 IU/d; 35µg/d) provided for a more linear relationship (mean serum 25(OH)D (nmol/l) = 0•044 × (total vitamin D) + 33•035). Although inputting an intake of 600 IU/d (i.e. the RDA) into the 95% lower CI curvilinear and linear models predicted a serum 25(OH)D of 54•4 and 55•2 nmol/l, respectively, the total vitamin D intake that would achieve 50 (and 40) nmol/l serum 25(OH)D was 359 (111) and 480 (260) IU/d, respectively. Inclusion of 95% range in the model to account for inter-individual variability increased the predicted intake of vitamin D needed to maintain serum 25(OH)D ≥50 nmol/l to 930 IU/d. The model used to describe the vitamin D intake–status relationship needs to be considered carefully when setting new reference intake values in Europe. | en |
| dc.description.sponsorship | European Commission (specific RTD Programme ‘Quality of Life and Management of Living Resources’, within the 6th Framework Programme (contract no. FP6-036196-2 EURRECA: EURopean micronutrient RECommendations Aligned)) | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Cashman, K. D.,Fitzgerald, A. P.,Kiely, M.,Seamans, K. M. (2011) 'A systematic review and meta-regression analysis of the vitamin D intake-serum 25-hydroxyvitamin D relationship to inform European recommendations'. British Journal of Nutrition, 106 (11), 1638–1648. doi:10.1017/S0007114511005058 | en |
| dc.identifier.doi | 10.1017/S0007114511005058 | |
| dc.identifier.endpage | 1648 | en |
| dc.identifier.issn | 1475-2662 | |
| dc.identifier.issued | 11 | en |
| dc.identifier.journaltitle | British Journal of Nutrition | en |
| dc.identifier.startpage | 1638 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/863 | |
| dc.identifier.volume | 106 | en |
| dc.language.iso | en | en |
| dc.publisher | Cambridge University Press | en |
| dc.rights | © The Authors 2011 | en |
| dc.subject | Regression analysis | en |
| dc.subject | Systematic reviews | en |
| dc.subject | Vitamin D requirements | en |
| dc.subject | Serum 25-hydroxyvitamin D | en |
| dc.subject | European Micronutrient Recommendations Aligned (EURRECA) | en |
| dc.title | A systematic review and meta-regression analysis of the vitamin D intake-serum 25-hydroxyvitamin D relationship to inform European recommendations | en |
| dc.type | Article (peer-reviewed) | en |
