dc.contributor.author	Fkiri, Anis
dc.contributor.author	Sellami, Badreddine
dc.contributor.author	Selmi, Aymen
dc.contributor.author	Khazri, Abdelhafidh
dc.contributor.author	Saidani, Wiem
dc.contributor.author	Imen, Bouzidi
dc.contributor.author	Sheehan, David
dc.contributor.author	Hamouda, Beyrem
dc.contributor.author	Smiri, Leila Samia
dc.contributor.funder	Ministère de l'Enseignement Supérieur et de la Recherche Scientifique, Tunisie	fr
dc.date.accessioned	2018-10-11T14:07:27Z
dc.date.available	2018-10-11T14:07:27Z
dc.date.issued	2018-07-05
dc.description.abstract	The increased use of gold nanoparticles (AuNPs) in several applications has led to a rise in concerns about their potential toxicity to aquatic organisms. In addition, toxicity of nanoparticles to aquatic organisms is related to their physical and chemical properties. In the present study, we synthesize two forms of gold octahedra nanoparticles (Au_0.03 and Au_0.045) in 1.3-propandiol with polyvinyl-pyrrolidone K30 (PVPK30) as capping agent using polyol process. Shape, size and optical properties of the particles could be tuned by changing the molar ratio of PVP K30 to metal salts. The anisotropy in nanoparticles shape shows strong localized surface plasmon resonance (SPR) in the near infrared region of the electromagnetic spectrum. Environmental impact of Oct-AuNPs was determined in the marine bivalve, Ruditapes decussatus exposed to different concentrations of Au_0.03 and Au_0.045. The dynamic light scattering showed the stability and resistance of Au_0.03 and Au_0.045 in the natural seawater. No significant modification in vg-like proteins, MDA level and enzymatic activities were observed in treated clams with Au_0.03 even at high concentration. In contrast, Au_0.045 induced superoxide dismutase (SOD), catalase (CAT), glutathione transferase (GST) activities, in a concentration dependent manner indicating defense against oxidative stress. Enhanced lipid peroxidation represented by malondialdehyde content confirmed oxidative stress of Au_0.045 at high concentration. These results highlight the importance of the physical form of nanomaterials on their interactions with marine organisms and provide a useful guideline for future use of Oct-AuNPs. In addition, Vitellogenin is shown not to be an appropriate biomarker for Oct-AuNPs contamination even at high concentration. We further show that Oct-AuNPs exhibit an important antioxidant response without inducing estrogenic disruption.	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Fkiri, A., Sellami, B., Selmi, A., Khazri, A., Saidani, W., Imen, B., Sheehan, D., Hamouda, B. and Smiri, L. S. (2018) 'Gold Octahedra nanoparticles (Au_0.03 and Au_0.045): Synthesis and impact on marine clams Ruditapes decussatus', Aquatic Toxicology, 202, pp. 97-104. doi: 10.1016/j.aquatox.2018.07.004	en
dc.identifier.doi	10.1016/j.aquatox.2018.07.004
dc.identifier.endpage	104	en
dc.identifier.issn	0166-445X
dc.identifier.journaltitle	Aquatic Toxicology	en
dc.identifier.startpage	97	en
dc.identifier.uri	https://hdl.handle.net/10468/7000
dc.identifier.volume	202	en
dc.language.iso	en	en
dc.publisher	Elsevier	en
dc.relation.uri	http://www.sciencedirect.com/science/article/pii/S0166445X18304120
dc.rights	© 2018 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	en
dc.subject	Gold nano-octahedra	en
dc.subject	Surface plasmon resonance	en
dc.subject	Ecotoxicology	en
dc.subject	Biomarkers	en
dc.subject	Biomonitoring	en
dc.subject	Oxidative stress	en
dc.title	Gold octahedra nanoparticles (Au_0.03 and Au_0.045): Synthesis and impact on marine clams Ruditapes decussatus	en
dc.type	Article (peer-reviewed)	en

Gold octahedra nanoparticles (Au_0.03 and Au_0.045): Synthesis and impact on marine clams Ruditapes decussatus

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