Bifidobacterium breve with a-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat

dc.contributor.authorPatterson, Elaine
dc.contributor.authorWall, Rebecca
dc.contributor.authorLisai, Sara
dc.contributor.authorRoss, R. Paul
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.authorFitzgerald, Gerald F.
dc.contributor.authorBanni, Sebastiano
dc.contributor.authorQuigley, Eamonn M.
dc.contributor.authorShanahan, Fergus
dc.contributor.authorStanton, Catherine
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2017-03-15T11:59:20Z
dc.date.available2017-03-15T11:59:20Z
dc.date.issued2017-03-07
dc.date.updated2017-03-15T11:54:33Z
dc.description.abstractThis study focused on the mechanisms that fatty acid conjugating strains - Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) either alone or in combination with B. breve NCIMB 702258 or B. breve DPC 6330 (109 CFU/day) or unsupplemented control diet for six weeks. The overall n-3 PUFA score was increased in all groups receiving the ALA enriched diet. Hepatic peroxisomal beta oxidation increased following supplementation of the ALA enriched diet with B. breve (P < 0.05) and so the ability of the strains to produce c9t11 conjugated linoleic acid (CLA) was identified in adipose tissue. Furthermore, a strain specific effect of B. breve NCIMB 702258 was found on the endocannabinoid system (ECS). Liver triglycerides (TAG) were reduced following ALA supplementation, compared with unsupplemented controls (P < 0.01) while intervention with B. breve further reduced liver TAG (P < 0.01), compared with the ALA enriched control. These data indicate that the interactions of the gut microbiota with fatty acid metabolism directly affect host health by modulating n-3 PUFA score and the ECS.en
dc.description.sponsorshipScience Foundation Ireland (Grant no. SFI/12/RC/2273)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPatterson, E., Wall, R., Lisai, S., Ross, R. P., Dinan, T. G., Cryan, J. F., Fitzgerald, G. F., Banni, S., Quigley, E. M., Shanahan, F. and Stanton, C. (2017) 'Bifidobacterium breve with α-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat', Scientific Reports, 7, pp. 43300. doi:10.1038/srep43300en
dc.identifier.doi10.1038/srep43300
dc.identifier.endpage43300-12en
dc.identifier.issn2045-2322
dc.identifier.journaltitleScientific Reportsen
dc.identifier.startpage43300-1en
dc.identifier.urihttps://hdl.handle.net/10468/3785
dc.identifier.volume7en
dc.language.isoenen
dc.publisherElsevieren
dc.rights© The Authors 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectApplied microbiologyen
dc.subjectClinical microbiologyen
dc.subjectExperimental models of diseaseen
dc.titleBifidobacterium breve with a-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of faten
dc.typeArticle (peer-reviewed)en
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