Bifidobacterium longum counters the effects of obesity: partial successful translation from rodent to human

dc.contributor.authorSchellekens, Harriët
dc.contributor.authorTorres-Fuentes, Cristina
dc.contributor.authorvan de Wouw, Marcel
dc.contributor.authorLong-Smith, Caitriona M.
dc.contributor.authorMitchell, Avery
dc.contributor.authorStrain, Conall R.
dc.contributor.authorBerding, Kirsten
dc.contributor.authorBastiaanssen, Thomaz F. S.
dc.contributor.authorRea, Kieran
dc.contributor.authorGolubeva, Anna V.
dc.contributor.authorArboleya, Silvia
dc.contributor.authorVerpaalen, Mathieu
dc.contributor.authorPusceddu, Matteo M.
dc.contributor.authorMurphy, Amy
dc.contributor.authorFouhy, Fiona
dc.contributor.authorMurphy, Kiera
dc.contributor.authorRoss, R. Paul
dc.contributor.authorRoy, Bernard L.
dc.contributor.authorStanton, Catherine
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2022-05-12T12:03:25Z
dc.date.available2022-05-12T12:03:25Z
dc.date.issued2021-01
dc.date.updated2022-05-12T11:33:50Z
dc.description.abstractThe human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B. longum APC1472 supplementation reduces body-mass index (BMI) in healthy overweight/obese individuals as the primary outcome. B. longum APC1472 effects on waist-to-hip ratio (W/H ratio) and on obesity-associated plasma biomarkers were analysed as secondary outcomes. B. longum APC1472 was administered to HFD-fed C57BL/6 mice in drinking water for 16 weeks. In the human intervention trial, participants received B. longum APC1472 or placebo supplementation for 12 weeks, during which primary and secondary outcomes were measured at the beginning and end of the intervention. B. longum APC1472 supplementation was associated with decreased bodyweight, fat depots accumulation and increased glucose tolerance in HFD-fed mice. While, in healthy overweight/obese adults, the supplementation of B. longum APC1472 strain did not change primary outcomes of BMI (0.03, 95% CI [-0.4, 0.3]) or W/H ratio (0.003, 95% CI [-0.01, 0.01]), a positive effect on the secondary outcome of fasting blood glucose levels was found (-0.299, 95% CI [-0.44, -0.09]). This study shows a positive translational effect of B. longum APC1472 on fasting blood glucose from a preclinical mouse model of obesity to a human intervention study in otherwise healthy overweight and obese individuals. This highlights the promising potential of B. longum APC1472 to be developed as a valuable supplement in reducing specific markers of obesity. This research was funded in part by Science Foundation Ireland in the form of a Research Centre grant (SFI/12/RC/2273) to APC Microbiome Ireland and by a research grant from Cremo S.A.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid103176en
dc.identifier.citationSchellekens, H., Torres-Fuentes, C., van de Wouw, M., Long-Smith, C. M., Mitchell, A., Strain, C. R., Berding, K., Bastiaanssen, T. F. S., Rea, K., Golubeva, A. V., Arboleya, S., Verpaalen, M., Pusceddu, M. M., Murphy, A., Fouhy, F., Murphy, K., Ross, R. P., Roy, B. L., Stanton, C., Dinan, T. G. and Cryan, J. F. (2021) 'Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human', Ebiomedicine, 63, 103176, (16pp). doi: 10.1016/j.ebiom.2020.103176en
dc.identifier.doi10.1016/j.ebiom.2020.103176en
dc.identifier.endpage16en
dc.identifier.issn2352-3964
dc.identifier.journaltitleEbiomedicineen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13172
dc.identifier.volume63en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectObesityen
dc.subjectTranslationalen
dc.subjectFasting blood glucoseen
dc.subjectGhrelinen
dc.subjectCortisolen
dc.subjectGut microbiotaen
dc.subjectProbioticen
dc.subjectBifidobacterium longumen
dc.titleBifidobacterium longum counters the effects of obesity: partial successful translation from rodent to humanen
dc.typeArticle (peer-reviewed)en
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