Epigenetic silencing by early life hypoxic stress programmes respiratory motor control

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dc.check.date2020-11-04
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorO'Connor, Karen M.
dc.contributor.authorDias, Maria L.
dc.contributor.authorMcDonald, Fiona B.
dc.contributor.authorO'Halloran, Ken D.
dc.date.accessioned2020-01-10T12:35:34Z
dc.date.available2020-01-10T12:35:34Z
dc.date.issued2019-11-04
dc.date.updated2019-11-14T09:54:03Z
dc.description.abstractPreterm birth is a risk factor for the development of cardiorespiratory complications. Infants that are born prematurely face myriad challenges due to physiological immaturity. Respiratory control impairments in early life including apnoea of prematurity with resultant disruption to systemic oxygen status can provoke long-term disability, including increased propensity to develop morbidities in later life such as sleep-disordered breathing. In rodents, exposure to intermittent hypoxia mimicking recurrent episodes of oxygen desaturation that are characteristic of apnoeas, provokes plasticity at multiple sites of the respiratory control network culminating in breathing instabilities, altered chemoreflex control of breathing and impaired respiratory motor nerve and muscle function. Persistent effects of stressors presenting during critical periods of early development may be sustained by epigenetic mechanisms. Such changes may be especially relevant to perinatal exposure to intermittent hypoxia since it is established that hypermethylation of genes encoding antioxidant enzymes underlies carotid body chemoreceptor sensitization and respiratory instability following exposure to intermittent hypoxia during postnatal development.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Connor, K. M., Dias, M. L., McDonald, F. and O'Halloran, K. D. (2019) 'Epigenetic silencing by early life hypoxic stress programmes respiratory motor control', Experimental Physiology, 105(1), pp. 3-4. doi: 10.1113/EP088244en
dc.identifier.doi10.1113/EP088244en
dc.identifier.eissn1469-445X
dc.identifier.endpage4en
dc.identifier.issn0958-0670
dc.identifier.issued1en
dc.identifier.journaltitleExperimental Physiologyen
dc.identifier.startpage3en
dc.identifier.urihttps://hdl.handle.net/10468/9485
dc.identifier.volume105en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.relation.urihttps://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/EP088244
dc.rights© 2019, the Authors. Experimental Physiology © 2019, The Physiological Society. This is the peer reviewed version of the following article: O'Connor, K. M., Dias, M. L., McDonald, F. and O'Halloran, K. D. (2019) 'Epigenetic silencing by early life hypoxic stress programmes respiratory motor control', Experimental Physiology, 105(1), pp. 3-4, doi: 10.1113/EP088244. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.subjectPreterm birthen
dc.subjectPhysiological immaturityen
dc.subjectCardiorespiratory complicationsen
dc.subjectApnoea of prematurityen
dc.subjectSleep-disordered breathingen
dc.subjectIntermittent hypoxiaen
dc.subjectRespiratory instabilityen
dc.subjectPostnatalen
dc.subjectDNA methylationen
dc.subjectHypoxic stressen
dc.subjectCardiorespiratory controlen
dc.titleEpigenetic silencing by early life hypoxic stress programmes respiratory motor controlen
dc.typeArticle (peer-reviewed)en
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